Association between Adiposity and Bone Mineral Density in Adults: Insights from a National Survey Analysis.
Association between Adiposity and Bone Mineral Density in Adults: Insights from a National Survey Analysis.
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肥胖与骨密度（BMD）密切相关。本研究的目的是调查成年人BMD与肥胖指标之间的关系，包括女性脂肪百分比（GPF），男性脂肪百分比（APF），总脂肪百分比（TPF），内脏脂肪组织百分比（VAT%）和总瘦体重百分比（TLM%）。研究人员使用1999年至2018年国家健康和营养检查调查（NHANES）的数据分析了11，615名18岁及以上的参与者。研究了BMD和肥胖指标之间的相关性，并探讨了基于性别和年龄的潜在差异。在完全校正模型中，TPF、APF、GPF、VAT%和BMD之间存在显著负相关，而TLM%和BMD呈正相关。按年龄和性别分层，TPF、GPF和VAT%始终与BMD呈负相关。在年轻成人组中，38.2%的TPF消除了BMD和TPF之间的负相关性。男性BMD与APF呈倒U型关系，峰值为35.6%，而中年组BMD和APF也呈类似关系，峰值为31.7%。这项大样本研究发现肥胖指标与BMD之间存在显著的负相关性，为肥胖与骨骼健康之间的复杂联系提供了有价值的启示。
Adiposity and bone mineral density (BMD) are closely associated. The aim of this research was to investigate the association between BMD and adiposity measures in adults, including gynoid percent fat (GPF), android percent fat (APF), total percent fat (TPF), visceral adipose tissue percent (VAT%), and total lean mass percent (TLM%). Participants (n = 11,615) aged 18 years and older were analyzed using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. Associations between BMD and adiposity measures were investigated, and potential differences based on gender and age were explored. Significant negative associations were observed among TPF, APF, GPF, VAT%, and BMD in the fully adjusted models, while TLM% and BMD were positively associated. Stratifying by age and sex, TPF, GPF, and VAT% consistently demonstrated a negative correlation with BMD. In the young adult group, a TPF of 38.2% eliminated the negative correlation between BMD and TPF. Male BMD exhibited an inverted U-shaped relationship with APF, peaking at 35.6%, while a similar pattern was observed for the middle-aged group BMD and APF, with a peak at 31.7%. This large-sample research found a significant negative association between adiposity measures and BMD, providing valuable revelations regarding the intricate connection between adiposity and bone health.
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