A fully implanted drug delivery system for peripheral nerve blocks in behaving animals.
A fully implanted drug delivery system for peripheral nerve blocks in behaving animals.
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DOI：
10.1016/j.jneumeth.2009.06.006
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发表时间：
2009-09-15
影响因子：
3
通讯作者：
Miller, Lee E.
中科院分区：
文献类型：
--
作者：
Pohlmeyer, Eric A.;Jordon, Luke R.;Kim, Peter;Miller, Lee E.
抑制周围神经功能可以用于神经系统或运动控制的许多研究。在动物模型中通过使用外周神经阻滞以暂时的方式实现这一点，允许研究损失的直接影响，和/或行为或运动控制的任何短期变化和适应，同时避免通常与永久性病变相关的并发症，如溃疡或自残。我们已经开发了一种方法，通过长期植入药物输送系统，快速和反复诱导恒河猴的暂时性，控制运动缺陷。该组件由神经套囊和皮下注射圆顶组成，并且已经证明可以有效地将局部麻醉剂直接输送到周围神经许多个月。使用这种组件进行正中神经和尺神经阻滞通常会导致猕猴手部和手腕力量损失超过80%。该组件还可通过阻断坐骨神经有效诱导兔的行走运动缺陷。有趣的是，虽然标准麻醉剂足以用于兔神经阻滞，但肾上腺素的加入对于在猴中实现显著的运动阻滞至关重要。
Inhibiting peripheral nerve function can be useful for many studies of the nervous system or motor control. Accomplishing this in a temporary fashion in animal models by using peripheral nerve blocks permits studies of the immediate effects of the loss, and/or any resulting short-term changes and adaptations in behavior or motor control, while avoiding the complications commonly associated with permanent lesions, such as sores or self-mutilation. We have developed a method of quickly and repeatedly inducing temporary, controlled motor deficits in rhesus macaque monkeys via a chronically implanted drug delivery system. This assembly consists of a nerve cuff and a subdermal injection dome, and has proved effective for delivering local anesthetics directly to peripheral nerves for many months. Using this assembly for median and ulnar nerve blocks routinely resulted in over 80% losses in hand and wrist strength for rhesus monkeys. The assembly was also effective for inducing ambulatory motor deficits in rabbits through blocks of the sciatic nerve. Interestingly, while standard anesthetics were sufficient for the rabbit nerve blocks, the inclusion of epinephrine was essential for achieving significant motor blockade in the monkeys.
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