Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection.
Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection.
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DOI：
10.1371/journal.pone.0239799
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Holick MF
中科院分区：
文献类型：
--
作者：
Maghbooli Z;Sahraian MA;Ebrahimi M;Pazoki M;Kafan S;Tabriz HM;Hadadi A;Montazeri M;Nasiri M;Shirvani A;Holick MF
旨在研究血清 25-羟基维生素 D 水平及其对不良临床结果的影响以及 SARS-CoV-2 感染引起的免疫功能参数和死亡率之间的关联。分析了 235 名感染 COVID-19 的患者的医院数据。根据 CDC 标准，在我们的研究患者中，74% 患有严重的 COVID-19 感染，32.8% 的维生素 D 充足。调整混杂因素后，维生素 D 充足与临床严重程度降低、住院患者死亡率、血清 C 反应蛋白 (CRP) 水平和淋巴细胞百分比增加之间存在显着相关性。维生素 D 充足的 40 岁以上患者中，只有 9.7% 死于感染，而 25(OH)D 循环水平< 30 ng/ml 的患者中有 20% 死于感染。血清 CRP（一种炎症标志物）的显着降低以及淋巴细胞百分比的增加表明，充足的维生素 D 也可能通过降低针对这种病毒感染的细胞因子风暴的风险来帮助调节免疫反应。因此，建议改善普通人群（尤其是住院患者）的维生素 D 状况，对于降低与感染 COVID-19 相关的发病率和死亡率的严重程度具有潜在益处。
To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection. The hospital data of 235 patients infected with COVID-19 were analyzed. Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage. Only 9.7% of patients older than 40 years who were vitamin D sufficient succumbed to the infection compared to 20% who had a circulating level of 25(OH)D< 30 ng/ml. The significant reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency also may help modulate the immune response possibly by reducing risk for cytokine storm in response to this viral infection. Therefore, it is recommended that improving vitamin D status in the general population and in particular hospitalized patients has a potential benefit in reducing the severity of morbidities and mortality associated with acquiring COVID-19.
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影响因子：
56.9
作者：
Lamers, Mart M.;Beumer, Joep;Clevers, Hans
通讯作者：
Clevers, Hans
DOI：
10.1136/bmj.i6583
发表时间：
2017-02-15
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Martineau AR;Jolliffe DA;Hooper RL;Greenberg L;Aloia JF;Bergman P;Dubnov-Raz G;Esposito S;Ganmaa D;Ginde AA;Goodall EC;Grant CC;Griffiths CJ;Janssens W;Laaksi I;Manaseki-Holland S;Mauger D;Murdoch DR;Neale R;Rees JR;Simpson S Jr;Stelmach I;Kumar GT;Urashima M;Camargo CA Jr
通讯作者：
Camargo CA Jr
影响因子：
4.5
作者：
Chen SJ;Wang SC;Chen YC
通讯作者：
Chen YC
DOI：
10.1258/ebm.2010.010061
发表时间：
2010-08
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Bruce D;Ooi JH;Yu S;Cantorna MT
通讯作者：
Cantorna MT
影响因子：
--
作者：
HOPESIMPSON, RE
通讯作者：
HOPESIMPSON, RE