Using Temporal Expectation to Assess Auditory Streaming in Mice.
Using Temporal Expectation to Assess Auditory Streaming in Mice.
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DOI：
10.3389/fnbeh.2018.00205
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发表时间：
2018
影响因子：
3
通讯作者：
Chadderton PT
中科院分区：
文献类型：
--
作者：
Chapuis GA;Chadderton PT
听觉流是环境声音被分离成离散感知对象的过程。在人类和其他灵长类动物的心理物理学实验中，听觉系统在这方面具有非凡的能力。然而，人们对潜在的神经机制知之甚少，部分原因是在非灵长类物种中缺乏合适的行为范式。小鼠是一种越来越受欢迎的模型，用于研究感知和行动的神经机制，因为一系列分子工具可以精确操纵神经回路。在这里，我们提出了一种新的行为任务，可用于评估听觉流在头部固定小鼠的感知方面。训练动物在两个同时呈现的等声纯音序列中的一个中检测目标声音。通过在25-30次试验的块中相对于试验开始在特定流中呈现目标声音（约2 s）或晚（约4 s）来操纵时间期望。动物在该任务上达到高性能（总体d' > 1），并且值得注意的是，它们的假警报对它们的行为状态非常有指导意义。事实上，与早期阻滞相比，晚期阻滞的假警报时间明显延迟，表明动物将不同的背景与其他相同的刺激相关联。更精细地，我们观察到假警报被定时到目标流中存在的声音的开始。这表明，动物可以选择性地遵循目标流，尽管存在干扰流。任务期间的细胞外电生理记录显示，声音处理是灵活调制的方式与行为结果的优化一致。总之，这些结果表明，知觉流可以推断通过假警报在小鼠中的时间，并提供了一个新的范式，研究神经元的选择性注意机制。
Auditory streaming is the process by which environmental sound is segregated into discrete perceptual objects. The auditory system has a remarkable capability in this regard as revealed in psychophysical experiments in humans and other primates. However, little is known about the underlying neuronal mechanisms, in part because of the lack of suitable behavioural paradigms in non-primate species. The mouse is an increasingly popular model for studying the neural mechanisms of perception and action because of the range of molecular tools enabling precise manipulation of neural circuitry. Here we present a novel behavioural task that can be used to assess perceptual aspects of auditory streaming in head-fixed mice. Animals were trained to detect a target sound in a one of two simultaneously presented, isochronous pure tone sequences. Temporal expectation was manipulated by presenting the target sound in a particular stream either early (~2 s) or late (~4 s) with respect to trial onset in blocks of 25–30 trials. Animals reached high performance on this task (d' > 1 overall), and notably their false alarms were very instructive of their behavioural state. Indeed, false alarm timing was markedly delayed for late blocks compared to early ones, indicating that the animals associated a different context to an otherwise identical stimulus. More finely, we observed that the false alarms were timed to the onset of the sounds present in the target stream. This suggests that the animals could selectively follow the target stream despite the presence of a distractor stream. Extracellular electrophysiological recordings during the task revealed that sound processing is flexibly modulated in a manner consistent with the optimisation of behavioural outcome. Together, these results indicate that the perceptual streaming can be inferred via the timing of false alarms in mice, and provide a new paradigm with which to investigate neuronal mechanisms of selective attention.
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影响因子：
16.2
作者：
Francis NA;Winkowski DE;Sheikhattar A;Armengol K;Babadi B;Kanold PO
通讯作者：
Kanold PO
影响因子：
25
作者：
Ahrens, Sandra;Jaramillo, Santiago;Yu, Kai;Ghosh, Sanchari;Hwang, Ga-Ram;Paik, Raehum;Lai, Cary;He, Miao;Huang, Z. Josh;Li, Bo
通讯作者：
Li, Bo
影响因子：
25
作者：
Jaramillo, Santiago;Zador, Anthony M.
通讯作者：
Zador, Anthony M.
DOI：
10.1073/pnas.81.14.4586
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CRICK, F
通讯作者：
CRICK, F
影响因子：
64.8
作者：
Mesgarani, Nima;Chang, Edward F.
通讯作者：
Chang, Edward F.