Enhanced auditory brainstem response and parental bonding style in children with gastrointestinal symptoms.
Enhanced auditory brainstem response and parental bonding style in children with gastrointestinal symptoms.
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DOI：
10.1371/journal.pone.0032913
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Fukudo S
中科院分区：
文献类型：
--
作者：
Seino S;Watanabe S;Ito N;Sasaki K;Shoji K;Miura S;Kozawa K;Nakai K;Sato H;Kanazawa M;Fukudo S
儿童肠易激综合征（IBS）的大脑电生理特性和父母关系的影响尚不清楚。我们假设患有慢性胃肠道（GI）症状（如IBS）的儿童可能会表现出夸大的脑干听觉诱发电位（BAEP）反应，并接受更多不充分的父母关系。7岁的孩子和他们的母亲（141对）参加了这次活动。BAEP通过75 dB咔哒声触发的1，000个脑电图波的总和来测量。母亲完成了他们的儿童躯体化量表（CSI）和父母债券工具（PBI）。CSI结果显示，66名（42%）没有GI症状的儿童（对照组）和75名（58%）有一种或多种GI症状的儿童（GI组）。GI组III波（右侧中位数4.10四分位距[3.95-4.24] ms，左侧4.04 [3.90-4.18] ms）的峰值潜伏期显著短于对照组（右侧4.18 [4.06-4.34] ms，p = 0.032，左侧4.13 [4.02-4.24] ms，p = 0.018）。 女性GI组右侧III波的峰值潜伏期（4.00 [3.90-4.18] ms）显著短于对照组（4.18 [3.97-4.31] ms，p = 0.034）。 男性GI组的BAEP与对照组无显著差异。GI评分与左侧III波的峰值潜伏期显著相关（rho =-0.192，p = 0.025）。 GI组（29）的母亲护理PBI评分显著低于对照组（31 [28.5-33]，p = 0.010），而GI组（16）的母亲过度保护PBI评分显著高于对照组（13 [10.5-16]，p = 0.024）。 女性的多元回归分析也支持这些结果。这表明，有慢性胃肠道症状的儿童有夸大的脑干反应的环境刺激和不适当的父母的行为加重这些症状。
The electrophysiological properties of the brain and influence of parental bonding in childhood irritable bowel syndrome (IBS) are unclear. We hypothesized that children with chronic gastrointestinal (GI) symptoms like IBS may show exaggerated brainstem auditory evoked potential (BAEP) responses and receive more inadequate parental bonding. Children aged seven and their mothers (141 pairs) participated. BAEP was measured by summation of 1,000 waves of the electroencephalogram triggered by 75 dB click sounds. The mothers completed their Children's Somatization Inventory (CSI) and Parental Bonding Instrument (PBI). CSI results revealed 66 (42%) children without GI symptoms (controls) and 75 (58%) children with one or more GI symptoms (GI group). The III wave in the GI group (median 4.10 interquartile range [3.95–4.24] ms right, 4.04 [3.90–4.18] ms left) had a significantly shorter peak latency than controls (4.18 [4.06–4.34] ms right, p = 0.032, 4.13 [4.02–4.24] ms left, p = 0.018). The female GI group showed a significantly shorter peak latency of the III wave (4.00 [3.90–4.18] ms) than controls (4.18 [3.97–4.31] ms, p = 0.034) in the right side. BAEP in the male GI group did not significantly differ from that in controls. GI scores showed a significant correlation with the peak latency of the III wave in the left side (rho = −0.192, p = 0.025). The maternal care PBI scores in the GI group (29) were significantly lower than controls (31 [28.5–33], p = 0.010), while the maternal over-protection PBI scores were significantly higher in the GI group (16) than controls (13 [10.5–16], p = 0.024). Multiple regression analysis in females also supported these findings. It is suggested that children with chronic GI symptoms have exaggerated brainstem responses to environmental stimuli and inadequate parental behaviors aggravate these symptoms.
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作者：
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