Whole-Brain Resting-State Functional Connectivity Patterns Associated With Pediatric Anxiety and Involuntary Attention Capture.
Whole-Brain Resting-State Functional Connectivity Patterns Associated With Pediatric Anxiety and Involuntary Attention Capture.
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与儿童焦虑和非自愿注意捕获相关的全脑静息状态功能连接模式。
DOI：
10.1016/j.bpsgos.2021.05.007
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发表时间：
2021-09
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
儿童焦虑症与多种功能性大脑网络的功能障碍以及空间注意力分配的改变有关。我们使用网络水平分析来表征静息状态功能连接（rs-fc）改变与1)焦虑症状和2)与儿童焦虑症相关的刺激驱动注意力的改变。我们假设焦虑与额顶叶、默认模式、扣带-眼窝和腹侧注意网络连通性的改变有关，而包括腹侧注意网络在内的焦虑相关连通性的改变同时与刺激驱动的注意偏差有关。儿童样本（n = 61；平均年龄= 10.6岁），其中约一半符合当前焦虑症的标准，完成了临床分析、注意力任务和rs-fc磁共振成像扫描。网络水平的分析检查了全脑rs-fc模式与临床评定的焦虑和非自愿注意力捕获相关。事后分析控制了共病症状。临床评定的焦虑升高与扣谷-眼窝网络内以及扣谷-眼窝网络与腹侧注意、默认模式和视觉网络之间连通性的改变有关。腹侧注意和扣环-眼窝网络之间的连通性与焦虑和刺激驱动的注意的变化有关。儿童焦虑与几个网络之间的异常连接模式有关，其中大多数网络包括扣眼-眼窝网络。这些结果有助于澄清与儿童焦虑相关的网络内部和网络之间的相互作用及其与注意力改变的关联，表明特定的网络连接可以针对改善与焦虑相关的特定改变过程。
Pediatric anxiety disorders are linked to dysfunction in multiple functional brain networks, as well as to alterations in the allocation of spatial attention. We used network-level analyses to characterize resting-state functional connectivity (rs-fc) alterations associated with 1) symptoms of anxiety and 2) alterations in stimulus-driven attention associated with pediatric anxiety disorders. We hypothesized that anxiety was related to altered connectivity of the frontoparietal, default mode, cingulo-opercular, and ventral attention networks and that anxiety-related connectivity alterations that include the ventral attention network would simultaneously be related to deviations in stimulus-driven attention. A sample of children (n = 61; mean = 10.6 years of age), approximately half of whom met criteria for a current anxiety disorder, completed a clinical assay, an attention task, and rs-fc magnetic resonance imaging scans. Network-level analyses examined whole-brain rs-fc patterns associated with clinician-rated anxiety and with involuntary capture of attention. Post hoc analyses controlled for comorbid symptoms. Elevated clinician-rated anxiety was associated with altered connectivity within the cingulo-opercular network, as well as between the cingulo-opercular network and the ventral attention, default mode, and visual networks. Connectivity between the ventral attention and cingulo-opercular networks was associated with variation in both anxiety and stimulus-driven attention. Pediatric anxiety is related to aberrant connectivity patterns among several networks, most of which include the cingulo-opercular network. These results help clarify the within- and between-network interactions associated with pediatric anxiety and its association with altered attention, suggesting that specific network connections could be targeted to improve specific altered processes associated with anxiety.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
5.7
作者：
Dosenbach NUF;Koller JM;Earl EA;Miranda-Dominguez O;Klein RL;Van AN;Snyder AZ;Nagel BJ;Nigg JT;Nguyen AL;Wesevich V;Greene DJ;Fair DA
通讯作者：
Fair DA
影响因子：
4.4
作者：
Backes C;Rühle F;Stoll M;Haas J;Frese K;Franke A;Lieb W;Wichmann HE;Weis T;Kloos W;Lenhof HP;Meese E;Katus H;Meder B;Keller A
通讯作者：
Keller A
影响因子：
12.8
作者：
Cisler JM;Koster EH
通讯作者：
Koster EH
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup