Tumor volume and subvolume concordance between FDG-PET/CT and diffusion-weighted MRI for squamous cell carcinoma of the cervix.
Tumor volume and subvolume concordance between FDG-PET/CT and diffusion-weighted MRI for squamous cell carcinoma of the cervix.
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DOI：
10.1002/jmri.23830
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发表时间：
2013-02
影响因子：
4.4
通讯作者：
Grigsby, Perry W.
中科院分区：
文献类型：
--
作者：
Olsen, Jeffrey R.;Esthappan, Jacqueline;DeWees, Todd;Narra, Vamsi R.;Dehdashti, Farrokh;Siegel, Barry A.;Schwarz, Julie K.;Grigsby, Perry W.
比较FDG-PET/CT和MRI成像对宫颈癌患者的评估。我们比较了FDG-PET上的肿瘤特征和弥散加权MRI（DWI）上的表观弥散系数（ADC）图，以评估两种功能成像技术的一致性。20例宫颈癌患者接受了治疗前FDG-PETCT和盆腔MRI。使用配准软件将图像与骨盆解剖结构刚性融合。PET图像上的肿瘤轮廓通过自动分割包含至少40%的最大标准化摄取值的区域来生成。DWI轮廓通过手动分割生成。使用[PET]/[ADC]体积比例、Dice系数和每个ADC轮廓表面的平均SUV等阈值评价肿瘤体积相似性。肿瘤子体积相似性通过ANOVA评估。[PET]/[ADC]体积比为0.88 ± 0.14。PET和ADC肿瘤轮廓之间的Dice系数为0.76 ± 0.06。ADC描绘的肿瘤表面的平均SUV等阈值为34 ± 4%。在FDG-PET上具有增加的代谢活性的子体积在DWI上也具有更受限的扩散（p < 0.0001，ANOVA）。FDG-PET和DWI在宫颈癌的功能成像之间观察到一致性。在FDG-PET上具有增加的代谢活性的肿瘤子体积通过DWI也具有更大的细胞密度。
To compare FDG-PET/CT and MRI imaging for evaluating patients with cervical cancer. We compared tumor characteristics on FDG-PET and apparent diffusion coefficient (ADC) maps on diffusion-weighted MRI (DWI) to evaluate concordance of two functional imaging techniques. Twenty women with cervical cancer underwent pre-treatment FDG-PETCT and pelvic MRI. Images were rigidly fused by pelvic anatomy using co-registration software. Tumor contours on PET images were generated by auto-segmentation of the region containing at least 40% of the maximum standardized uptake value. DWI contours were generated by manual segmentation. Tumor volume similarity was evaluated using the [PET]/[ADC] volume proportion, Dice’s coefficient, and the mean SUV iso-threshold at the surface of each ADC contour. Tumor sub-volume similarity was evaluated ANOVA. The [PET]/[ADC] volume proportion was 0.88 ± 0.14. Dice’s coefficient between PET and ADC tumor contours was 0.76 ± 0.06. The mean SUV isothreshold at the ADC-delineated tumor surface was 34 ± 4%. Sub-volumes with increased metabolic activity on FDG-PET also had more restricted diffusion on DWI (p < 0.0001, ANOVA). Concordance of functional imaging is observed between FDG-PET and DWI for cervical cancer. Tumor sub-volumes with increased metabolic activity on FDG-PET also have greater cell density by DWI.
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DOI：
10.1016/s0360-3016(02)02705-0
发表时间：
2002-06-01
影响因子：
7
作者：
Miller, TR;Grigsby, PW
通讯作者：
Grigsby, PW
影响因子：
8.9
作者：
Rizzo, S.;Summers, P.;Bellomi, M.
通讯作者：
Bellomi, M.
影响因子：
3.3
作者：
Ogura, Akio;Hayakawa, Katsumi;Maeda, Fumie
通讯作者：
Maeda, Fumie
影响因子：
120.7
作者：
Schwarz, Julie K.;Siegel, Barry A.;Grigsby, Perry W.
通讯作者：
Grigsby, Perry W.
影响因子：
1.3
作者：
Liu, Ying;Bai, Renju;Wang, Dehua
通讯作者：
Wang, Dehua