Behaviorally inhibited temperament is associated with severity of post-traumatic stress disorder symptoms and faster eyeblink conditioning in veterans.
Behaviorally inhibited temperament is associated with severity of post-traumatic stress disorder symptoms and faster eyeblink conditioning in veterans.
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DOI：
10.3109/10253890.2011.578184
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Servatius RJ
中科院分区：
文献类型：
--
作者：
Myers CE;Vanmeenen KM;McAuley JD;Beck KD;Pang KC;Servatius RJ
以前的研究有时表明，创伤后应激障碍(PTSD)患者容易获得经典条件反应和/或对消退的抵抗。然而，目前尚不清楚这些行为是由于创伤后应激障碍或暴露在创伤中而获得的，还是反映了先前存在的导致创伤后应激障碍易感性的危险因素。在这里，我们研究了退伍军人的经典眨眼条件和消退，这些退伍军人自我评估了目前的创伤后应激障碍症状、战斗暴露以及行为抑制(BI)的个性特征，行为抑制(BI)是创伤后应激障碍的一个风险因素。招募了128名退伍军人(平均年龄51.2岁；13.3%为女性)；126人完成了自我评估，25.4%的人报告了战斗暴露史，30.9%的人报告了严重的当前创伤后应激障碍症状(PTSS)。创伤后应激障碍症状的严重程度与当前的BI相关(R2=0.497)，根据当前的BI和作战历史可以预测创伤后应激障碍的状态(80.2%的正确分类)。退伍军人中的一部分(n=87)也完成了眨眼条件反射。在没有PTSS的退伍军人中，童年时期的BI与更快的习得有关；在某些情况下，患有PTSS的退伍军人表现出延迟的灭绝。这些数据表明了当前的BI和PTSS之间的关系，并表明有时在PTSD患者中观察到的促进条件作用可能部分反映了个性特征，如童年BI，这些个性特征在PTSD的易感性之前就存在并促成了这一点。
Prior studies have sometimes demonstrated facilitated acquisition of classically-conditioned responses and/or resistance to extinction in post-traumatic stress disorder (PTSD). However, it is unclear whether these behaviors are acquired as a result of PTSD or exposure to trauma, or reflect pre-existing risk factors that confer vulnerability for PTSD. Here, we examined classical eyeblink conditioning and extinction in veterans self-assessed for current PTSD symptoms, exposure to combat, and the personality trait of behavioral inhibition (BI), a risk factor for PTSD. 128 veterans were recruited (mean age 51.2 years; 13.3% female); 126 completed self-assessment, with 25.4% reporting a history of exposure to combat and 30.9% reporting severe, current PTSD symptoms (PTSS). PTSD symptom severity was correlated with current BI (R2=0.497) and PTSS status could be predicted based on current BI and combat history (80.2% correct classification). A subset of the veterans (n=87) also completed eyeblink conditioning. Among veterans without PTSS, childhood BI was associated with faster acquisition; veterans with PTSS showed delayed extinction, under some conditions. These data demonstrate a relationship between current BI and PTSS, and suggest that the facilitated conditioning sometimes observed in PTSD patients may partially reflect personality traits such as childhood BI that pre-date and contribute to vulnerability for PTSD.
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影响因子：
1.6
作者：
Beck, Kevin D.;McLaughlin, Joselyn;Servatius, Richard J.
通讯作者：
Servatius, Richard J.
影响因子：
4.6
作者：
Grillon, C;Morgan, CA
通讯作者：
Morgan, CA
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
11.3
作者：
Gladstone, G;Parker, G
通讯作者：
Parker, G
DOI：
10.1097/00004583-199201000-00016
发表时间：
1992-01-01
影响因子：
13.3
作者：
HIRSHFELD, DR;ROSENBAUM, JF;KAGAN, J
通讯作者：
KAGAN, J