Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes.

Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes.
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三维柔性纳米级现场效应晶体管作为局部生物探测器。

DOI:
10.1126/science.1192033
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发表时间:
2010-08-13
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Lieber CM
Lieber CM
中科院分区:
其他
文献类型:
--
作者:
Tian B;Cohen-Karni T;Qing Q;Duan X;Xie P;Lieber CM

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纳米电子器件为研究生物系统提供了巨大的潜力,尽管几乎所有的工作都集中在平面器件设计上。我们已经克服了这一限制,通过在锐角扭结的硅纳米线的顶端合成集成了纳米场效应晶体管(NanFET)设备,其中纳米级的连接是由扭结的纳米结构的手臂进行的,并且远程多层互连允许三维(3D)探针呈现。设计和合成了锐角探针几何结构,通过控制相邻扭结之间的顺反向构象,并通过调制掺杂实现了纳米FET的局域化。三维纳米场效应管探针在水溶液中表现出与大的机械变形无关的电导和灵敏度,并表现出高的pH灵敏度。此外,用磷脂双层修饰的3D纳米探针可以进入单个细胞,从而实现对细胞内电位的稳健记录。
Nanoelectronic devices offer substantial potential for interrogating biological systems, although nearly all work has focused on planar device designs. We have overcome this limitation through synthetic integration of a nanoscale field effect transistor (nanoFET) device at the tip of an acute-angle kinked silicon nanowire, where nanoscale connections are made by the arms of the kinked nanostructure and remote multilayer interconnects allow three-dimensional (3D) probe presentation. The acute-angle probe geometry was designed and synthesized by controlling cis versus trans crystal conformations between adjacent kinks, and the nanoFET was localized through modulation doping. 3D nanoFET probes exhibited conductance and sensitivity in aqueous solution independent of large mechanical deflections, and demonstrated high pH sensitivity. Additionally, 3D nanoprobes modified with phospholipid bilayers can enter single cells to allow robust recording of intracellular potentials.
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