Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
复制标题
在年轻人冠状动脉风险发展（CARDIA）研究中，成年早期的血脂谱与表观遗传衰老相关。
DOI：
10.1186/s13148-021-01222-2
复制
发表时间：
2022-01-31
影响因子：
5.7
通讯作者：
Hou L
中科院分区：
文献类型：
--
作者：
Gao T;Wilkins JT;Zheng Y;Joyce BT;Jacobs DR Jr;Schreiner PJ;Horvath S;Greenland P;Lloyd-Jones D;Hou L
年龄加速度（GAA）是一种代表生理老化的表观遗传标记，与动脉粥样硬化性心血管疾病有关。然而，成年早期脂质水平和中年GAA之间的关联尚不清楚。此外，尚不清楚GAA是否介导年轻人脂质水平与中年亚临床动脉粥样硬化之间的关联。我们估计了1118名白色和黑人参与者在15和20年检查时的表观遗传年龄加速的指标，这些参与者来自年轻人冠状动脉风险发展（CARDIA）研究。我们使用多变量回归模型来检查Y15和Y20 GAA估计值与先前检查年（Y 0，Y 5和Y10）测量的血脂水平以及同时测量的甘油三酯（TG），低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平的相关性。中介分析用于评估GAA在多大程度上可能介导血脂和冠状动脉钙化（CAC）之间的关联。在我们的研究中，累积TG水平每高1-SD，GAA平均年龄就大0.73 ± 0.12岁。累积HDL-C水平每升高1个SD，GAA平均年轻0.57 ± 0.17岁。分层分析显示，TG和GAA之间的关联在女性和黑人参与者中更强，HDL-C和GAA之间的关联在女性和白色参与者中更强。在统计学上，GAA介导累积TG与CAC的相关性为17.4%。成年早期的高TG和低HDL-C与中年的加速表观遗传衰老有关。增加的表观遗传年龄加速可能部分介导高TG水平和亚临床动脉粥样硬化之间的关联。在线版本包含补充材料，可通过10.1186/s13148-021-01222-2获得。
GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular disease. However, the associations between early adulthood lipid levels and GAA in midlife are unknown. Also, it is unknown whether GAA mediates the associations between lipid levels in young adults and subclinical atherosclerosis in midlife. We estimated measures of epigenetic age acceleration in 1118 White and Black participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at examination years (Y) 15 and 20. We used multivariable regression models to examine associations of Y15 and Y20 GAA estimates with plasma lipid levels measured at prior examination years (Y0, Y5, and Y10) and concurrently: triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels. Mediation analysis was used to assess the extent to which GAA may mediate associations between plasma lipids and coronary artery calcification (CAC). In our study each 1-SD higher cumulative TG level was associated with an average 0.73 ± 0.12 years older GAA. Each 1-SD higher cumulative HDL-C level was associated with an average 0.57 ± 0.17 years younger GAA. Stratified analyses showed that the associations between TG and GAA were stronger among female and Black participants and the associations between HDL-C and GAA were stronger among female and White participants. GAA statistically mediated 17.4% of the association of cumulative TG with CAC. High TG and low HDL-C in early adulthood are associated with accelerated epigenetic aging by midlife. Increased epigenetic age acceleration may partially mediate the associations between high TG levels and the presence of subclinical atherosclerosis. The online version contains supplementary material available at 10.1186/s13148-021-01222-2.
登录
查看更多内容
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.1161/01.atv.20.12.2670
发表时间：
2000-12-01
影响因子：
8.7
作者：
Asztalos, BF;Roheim, PS;Schaefer, EJ
通讯作者：
Schaefer, EJ
影响因子：
5.7
作者：
Nannini, Drew R.;Joyce, Brian T.;Hou, Lifang
通讯作者：
Hou, Lifang
影响因子：
5
作者：
Carr, JJ;Crouse, JR;Burke, GL
通讯作者：
Burke, GL
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R