DWI-based MR thermometry: could it discriminate Alzheimer’s disease from mild cognitive impairment and healthy subjects?
DWI-based MR thermometry: could it discriminate Alzheimer’s disease from mild cognitive impairment and healthy subjects?
复制标题
基于 DWI 的 MR 测温：它能否区分阿尔茨海默病、轻度认知障碍和健康受试者？
DOI：
10.1007/s00234-022-02969-y
复制
发表时间：
2022
期刊：
影响因子：
2.8
通讯作者：
Tali E. Turgut
中科院分区：
文献类型：
--
作者：
Asfuro?lu Berrak Barutcu;Topkan Tu?berk Anda?;Kaydu Nesrin Erdo?an;Sakai Koji;?ner Ali Yusuf;Karaman Yahya;Yamada Kei;Tali E. Turgut
目的本研究的目的是使用基于扩散加权成像（DWI）的磁共振（MR）测温法比较阿尔茨海默病（AD）、轻度认知障碍（MCI）患者和健康受试者（HS）的侧脑室内脑脊液（CSF）温度。方法72例患者本研究纳入2018年9月至2019年8月期间接受3-T MR检查的AD患者37例，MCI患者19例，HS患者16例。记录吸烟习惯、受教育程度、疾病持续时间和合并症状况。使用简易精神状态检查（MMSE）和临床痴呆评定（CDR）评分对患者进行评估。使用基于DWI的MR测温法测量脑温度。使用Pearson卡方检验、Mann-Whitney检验和Kruskal-Wallis检验进行脑温的组比较。使用事后Bonferroni检验进行进一步分析。结果AD患者CDR评分为0.5、1、2分者分别为2例（5.4%）、14例（37.8%）、21例（56.8%）。中位MMSE评分在组间和两两比较中有显著差异。中位CSF温度（°C）值显示组间存在统计学显著差异（HS：38.5 °C，MCI：38.17 °C，AD：38.0 °C）。事后Mann-WhitneyU检验表明AD患者和HS之间存在显著差异（p= 0.009）。有没有显着的CSF温度差异，在其他成对comparation. ConclusionLowerCSF温度在AD患者中观察到比HS，可能是由于降低脑代谢在AD。基于DWI的MR测温作为一种无创成像方法，能够测量CSF温度，可能有助于AD的诊断。
PurposeThe aim of this study is to compare lateral ventricular cerebrospinal fluid (CSF) temperature of the patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and healthy subjects (HS) using diffusion-weighted imaging (DWI)-based magnetic resonance (MR) thermometry.MethodsSeventy-two patients (37 AD, 19 MCI, 16 HS) who underwent 3-T MR examination from September 2018 to August 2019 were included in this study. Smoking habits, education level, disease duration, and comorbidity status were recorded. Patients were assessed using Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR) score. Brain temperatures were measured using DWI-based MR thermometry. Group comparisons of brain temperature were performed using the Pearson chi-square, Mann–Whitney, and Kruskal–Wallis tests. Further analysis was performed using the post hoc Bonferroni test. Receiver operating characteristic (ROC) analysis was also used.ResultsA CDR score of 0.5, 1, and 2 was 2 (5.4%), 14 (37.8%), and 21 (56.8%) in AD, respectively. The median MMSE score had significant differences among groups and also in pairwise comparisons. The median CSF temperature (°C) values showed statistically significant difference among groups (HS: 38.5 °C, MCI: 38.17 °C, AD: 38.0 °C). The post hoc Mann–WhitneyUtest indicated a significant difference between AD patients and HS (p= 0.009). There were no significant CSF temperature differences in other pairwise comparisons.ConclusionLower CSF temperatures were observed in AD patients than in HS, probably due to decreased brain metabolism in AD. DWI-based MR thermometry as a noninvasive imaging method enabling the measurement of CSF temperatures may contribute to the diagnosis of AD.
登录
查看更多内容
影响因子：
3.3
作者：
Mingming Zhu;J. Ackerman;A. Sukstanskii;D. Yablonskiy
通讯作者：
Mingming Zhu;J. Ackerman;A. Sukstanskii;D. Yablonskiy
影响因子：
7.4
作者：
Yin, Fei;Sancheti, Harsh;Patil, Ishan;Cadenas, Enrique
通讯作者：
Cadenas, Enrique
影响因子：
15.9
作者：
KETY, SS;SCHMIDT, CF
通讯作者：
SCHMIDT, CF
DOI：
10.1016/0021-9681(56)90146-1
发表时间：
1956-05-01
期刊：
Journal of chronic diseases
影响因子：
--
作者：
KETY, S S
通讯作者：
KETY, S S
影响因子：
3.3
作者：
Tofts, Paul S.;Jackson, Jonathan S.;Tozer, Daniel J.;Cercignani, Mara;Keir, Geoffrey;MacManus, David G.;Ridgway, Gerard R.;Ridha, Basil H.;Schmierer, Klaus;Siddique, Durre;Thornton, John S.;Wroe, Stephen J.;Fox, Nick C.
通讯作者：
Fox, Nick C.