Characterization of Per- and Polyfluorinated Alkyl Substances Present in Commercial Anti-fog Products and Their In Vitro Adipogenic Activity.
Characterization of Per- and Polyfluorinated Alkyl Substances Present in Commercial Anti-fog Products and Their In Vitro Adipogenic Activity.
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商业防雾产品中全氟化和多氟化烷基物质的表征及其体外脂肪生成活性。
DOI：
10.1021/acs.est.1c06990
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发表时间：
2022-01-18
影响因子：
11.4
通讯作者：
Stapleton HM
中科院分区：
文献类型：
--
作者：
Herkert NJ;Kassotis CD;Zhang S;Han Y;Pulikkal VF;Sun M;Ferguson PL;Stapleton HM
眼镜上使用防雾喷雾剂和溶液，以最大程度地减少水蒸气的凝结，尤其是在佩戴口罩时。鉴于其防水特性，我们试图表征四种防雾喷雾产品、五种防雾布产品和两种疑似用于制备防雾产品的商业含氟表面活性剂配方中的全氟烷基物质和多氟烷基物质 (PFAS) 化合物。所有产品和配方中均检测到含氟调聚物醇 (FTOH) 和含氟调聚物乙氧基化物 (FTEO)。虽然 6:2 FTOH 和 6:2 FTEO 聚合物系列占主导地位，但一种防雾布和一种配方包含 8:2、10:2、12:2、14:2 和 16:2 FTOH 和 FTEO 聚合物系列。样品中的 PFAS 浓度各不相同，在防雾喷雾中检测到的 PFAS 浓度高达 25,000 μg/mL，在防雾布产品中检测到的浓度高达 185,000 μg（g 布）−1。防雾产品的总有机氟 (TOF) 测量值在喷雾剂中为 190 至 20,700 μg/mL，在布料中为 44,200 至 131,500 μg（g 布）−1。量化的 FTOH 和 FTEO 占 TOF 质量的 1−99%。此外，所有四种防雾喷雾剂和两种商业制剂在小鼠 3T3-L1 细胞中均表现出显着的细胞毒性和脂肪形成活性（甘油三酯积累和/或前脂肪细胞增殖）。结果表明，FTEO 是防雾喷雾剂所表现出的脂肪形成活性的重要贡献者。总而言之，这些结果表明 FTEO 以毒理学相关水平存在于商业产品中，需要更多的研究来充分了解使用这些含有 PFAS 的产品所带来的健康风险。
Anti-fog sprays and solutions are used on eyeglasses to minimize the condensation of water vapor, particularly while wearing a mask. Given their water-repellent properties, we sought to characterize per- and polyfluorinated alkyl substance (PFAS) compounds in four anti-fog spray products, five anti-fog cloth products, and two commercial fluorosurfactant formulations suspected to be used in preparing anti-fog products. Fluorotelomer alcohols (FTOHs) and fluorotelomer ethoxylates (FTEOs) were detected in all products and formulations. While 6:2 FTOH and the 6:2 FTEO polymeric series were predominant, one anti-fog cloth and one formulation contained 8:2, 10:2, 12:2, 14:2, and 16:2 FTOH and FTEO polymeric series. PFAS concentrations varied in samples and were detected at levels up to 25,000 μg/mL in anti-fog sprays and 185,000 μg (g cloth)−1 in anti-fog cloth products. The total organic fluorine (TOF) measurements of anti-fog products ranged from 190 to 20,700 μg/mL in sprays and 44,200 to 131,500 μg (g cloth)−1 in cloths. Quantified FTOHs and FTEOs accounted for 1−99% of TOF mass. In addition, all four anti-fog sprays and both commercial formulations exhibited significant cytotoxicity and adipogenic activity (either triglyceride accumulation and/or pre-adipocyte proliferation) in murine 3T3-L1 cells. Results suggest that FTEOs are a significant contributor to the adipogenic activity exhibited by the anti-fog sprays. Altogether, these results suggest that FTEOs are present in commercial products at toxicologically relevant levels, and more research is needed to fully understand the health risks from using these PFAS-containing products.
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影响因子：
11.4
作者：
Ellis, DA;Martin, JW;Wallington, TJ
通讯作者：
Wallington, TJ
影响因子：
11.8
作者：
Caron-Beaudoin, Elyse;Ayotte, Pierre;Lemire, Melanie
通讯作者：
Lemire, Melanie
影响因子：
11.8
作者：
Fraser, Alicia J.;Webster, Thomas F.;Watkins, Deborah J.;Strynar, Mark J.;Kato, Kayoko;Calafat, Antonia M.;Vieira, Veronica M.;McClean, Michael D.
通讯作者：
McClean, Michael D.
影响因子：
11.4
作者：
Fraser, Alicia J.;Webster, Thomas F.;Watkins, Deborah J.;Nelson, Jessica W.;Stapleton, Heather M.;Calafat, Antonia M.;Kato, Kayoko;Shoeib, Mahiba;Vieira, Veronica M.;McClean, Michael D.
通讯作者：
McClean, Michael D.
DOI：
10.1021/acsestwater.1c00047
发表时间：
2021-05-13
期刊：
ACS ES&T WATER
影响因子：
--
作者：
Han, Yuling;Pulikkal, Vivek Francis;Sun, Mei
通讯作者：
Sun, Mei