Polyfluorinated compounds in dust from homes, offices, and vehicles as predictors of concentrations in office workers' serum.
Polyfluorinated compounds in dust from homes, offices, and vehicles as predictors of concentrations in office workers' serum.
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DOI：
10.1016/j.envint.2013.08.012
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发表时间：
2013-10
影响因子：
11.8
通讯作者：
McClean, Michael D.
中科院分区：
文献类型：
--
作者：
Fraser, Alicia J.;Webster, Thomas F.;Watkins, Deborah J.;Strynar, Mark J.;Kato, Kayoko;Calafat, Antonia M.;Vieira, Veronica M.;McClean, Michael D.
我们的目的是表征多氟化合物（PFCs）在室内灰尘从办公室，家庭和车辆的水平;调查可能影响PFC的灰尘水平的因素;并检查PFCs在灰尘和办公室工作人员的血清之间的关联。2009年从马萨诸塞州波士顿的31名个人的办公室、家庭和车辆中收集了灰尘样本，并分析了19种全氟辛烷磺酸，包括全氟辛酸盐（PFOA）、全氟辛烷磺酸（PFOS）、氟调聚物醇（FTOH）和磺酰胺乙醇（FOSE）。从每个参与者身上采集血清，分析八种全氟辛烷磺酸，包括全氟辛酸和全氟辛烷磺酸。全氟壬酸、全氟辛酸、全氟庚酸、全氟己酸、全氟辛烷磺酸和8：2 FTOH在所有三种微环境的灰尘中的检出率均>50%。办公室灰尘中的最高几何平均浓度为8：2 FTOH（309纳克/克），而全氟辛烷磺酸在家庭（26.9纳克/克）和车辆（15.8纳克/克）中的浓度最高。总的来说，办公室的全氟化学品浓度最高，特别是长链羧酸和全氟辛烷磺酸。全氟丁酸盐普遍存在于家庭和车辆中，但不是办公室。在调整办公室空气中的PFC浓度后，PFOA血清浓度与PFC粉尘水平无关。大多数全氟化学品在办公室的粉尘浓度高于家庭和车辆。然而，室内灰尘可能不是办公室工作人员接触全氟化学品的重要来源。这一发现表明，我们以前发表的观察办公室空气中的FTOH浓度和办公室工作人员中的PFOA浓度之间的关联并不是由于灰尘中的PFCs的混淆。
We aimed to characterize levels of polyfluorinated compounds (PFCs) in indoor dust from offices, homes, and vehicles; to investigate factors that may affect PFC levels in dust; and to examine the associations between PFCs in dust and office workers’ serum. Dust samples were collected in 2009 from offices, homes, and vehicles of 31 individuals in Boston, MA and analyzed for nineteen PFCs, including perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), fluorotelomer alcohols (FTOHs), and sulfonamidoethanols (FOSEs). Serum was collected from each participant and analyzed for eight PFCs including PFOA and PFOS. Perfluorononanoate, PFOA, perfluoroheptanoate, perfluorohexanoate, PFOS and 8:2 FTOH had detection frequencies >50% in dust from all three microenvironments. The highest geometric mean concentration in office dust was for 8:2 FTOH (309 ng/g), while PFOS was highest in homes (26.9 ng/g) and vehicles (15.8 ng/g). Overall, offices had the highest PFC concentrations, particularly for longer-chain carboxylic acids and FTOHs. Perfluorobutyrate was prevalent in homes and vehicles, but not offices. PFOA serum concentrations were not associated with PFC dust levels after adjusting for PFC concentrations in office air. Dust concentrations of most PFCs are higher in offices than in homes and vehicles. However, indoor dust may not be a significant source of exposure to PFCs for office workers. This finding suggests that our previously published observation of an association between FTOH concentrations in office air and PFOA concentrations in office workers was not due to confounding by PFCs in dust.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
DOI：
10.1038/jes.2009.73
发表时间：
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作者：
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影响因子：
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作者：
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