Polyfluorinated compounds in serum linked to indoor air in office environments.

Polyfluorinated compounds in serum linked to indoor air in office environments.
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DOI:
10.1021/es2038257
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发表时间:
2012-01-17
影响因子:
11.4
通讯作者:
McClean, Michael D.
McClean, Michael D.
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Fraser, Alicia J.;Webster, Thomas F.;Watkins, Deborah J.;Nelson, Jessica W.;Stapleton, Heather M.;Calafat, Antonia M.;Kato, Kayoko;Shoeib, Mahiba;Vieira, Veronica M.;McClean, Michael D.

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我们的目的是调查的作用,室内办公室的空气中暴露于多氟化合物(PFCs)的办公室工作人员。2009年冬季,在马萨诸塞州波士顿的31个办公室进行了为期一周的主动空气采样。分析了空气样品中的氟调聚物醇(FTOH)、磺胺(FOSA)和磺酰胺乙醇(FOSE)。从每个参与者(n=31)收集血清,并分析了12种全氟辛烷磺酸,包括全氟辛酸和全氟辛烷磺酸。在空气中,FTOH的浓度最高,特别是8:2-FTOH(GM= 9,920 pg/m3)。FTOH因建筑物而异,在新建建筑物中观察到的水平最高。血清中PFOA与空气中6:2-FTOH(r=0.43)、8:2-FTOH(r=0.60)和10:2-FTOH(r=0.62)浓度显著相关。总的来说,空气中的FTOHs显著预测了血清中的PFOA(p < 0.001),并解释了血清PFOA浓度变化的约36%。血清中的全氟辛烷磺酸与空气中的全氟辛烷磺酸/全氟辛烷磺酸浓度无关。总之,办公室空气中的FTOH浓度显著预测办公室工作人员血清中的PFOA浓度。不同建筑物的全氟化碳空气浓度差异很可能是由于地毯、家具和/或油漆等潜在来源的数量、类型和使用年限不同。
We aimed to investigate the role of indoor office air on exposure to polyfluorinated compounds (PFCs) among office workers. Week-long, active air sampling was conducted during the winter of 2009 in 31 offices in Boston, MA. Air samples were analyzed for fluorotelomer alcohols (FTOHs), sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs). Serum was collected from each participant (n=31) and analyzed for twelve PFCs including PFOA and PFOS. In air, FTOHs were present in the highest concentrations, particularly 8:2-FTOH (GM=9,920 pg/m3). FTOHs varied significantly by building with the highest levels observed in a newly constructed building. PFOA in serum was significantly correlated with air levels of 6:2-FTOH (r=0.43), 8:2-FTOH (r=0.60), and 10:2-FTOH (r=0.62). Collectively, FTOHs in air significantly predicted PFOA in serum (p < 0.001) and explained approximately 36% of the variation in serum PFOA concentrations. PFOS in serum was not associated with air levels of FOSAs/FOSEs. In conclusion, FTOH concentrations in office air significantly predict serum PFOA concentrations in office workers. Variation in PFC air concentrations by building is likely due to differences in the number, type, and age of potential sources such as carpeting, furniture and/or paint.
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