Polyfluorinated compounds in serum linked to indoor air in office environments.
Polyfluorinated compounds in serum linked to indoor air in office environments.
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DOI:
10.1021/es2038257
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发表时间:
2012-01-17
影响因子:
11.4
通讯作者:
McClean, Michael D.
中科院分区:
文献类型:
--
作者:
Fraser, Alicia J.;Webster, Thomas F.;Watkins, Deborah J.;Nelson, Jessica W.;Stapleton, Heather M.;Calafat, Antonia M.;Kato, Kayoko;Shoeib, Mahiba;Vieira, Veronica M.;McClean, Michael D.
We aimed to investigate the role of indoor office air on exposure to polyfluorinated compounds (PFCs) among office workers. Week-long, active air sampling was conducted during the winter of 2009 in 31 offices in Boston, MA. Air samples were analyzed for fluorotelomer alcohols (FTOHs), sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs). Serum was collected from each participant (n=31) and analyzed for twelve PFCs including PFOA and PFOS. In air, FTOHs were present in the highest concentrations, particularly 8:2-FTOH (GM=9,920 pg/m3). FTOHs varied significantly by building with the highest levels observed in a newly constructed building. PFOA in serum was significantly correlated with air levels of 6:2-FTOH (r=0.43), 8:2-FTOH (r=0.60), and 10:2-FTOH (r=0.62). Collectively, FTOHs in air significantly predicted PFOA in serum (p < 0.001) and explained approximately 36% of the variation in serum PFOA concentrations. PFOS in serum was not associated with air levels of FOSAs/FOSEs. In conclusion, FTOH concentrations in office air significantly predict serum PFOA concentrations in office workers. Variation in PFC air concentrations by building is likely due to differences in the number, type, and age of potential sources such as carpeting, furniture and/or paint.
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影响因子:
10.4
作者:
Olsen, Geary W;Church, Timothy R;Miller, John P;Burris, Jean M;Hansen, Kristen J;Lundberg, James K;Armitage, John B;Herron, Ross M;Medhdizadehkashi, Zahra;Nobiletti, John B;O'Neill, E Mary;Mandel, Jeffrey H;Zobel, Larry R
通讯作者:
Zobel, Larry R
影响因子:
10.4
作者:
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
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Needham, Larry L
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Jensen, Allan Astrup;Leffers, Henrik
通讯作者:
Leffers, Henrik
影响因子:
11.4
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De Silva, AO;Mabury, SA
通讯作者:
Mabury, SA
影响因子:
11.4
作者:
Shoeib, M;Harner, T;Zhu, JP
通讯作者:
Zhu, JP