Quantitative anatomy mimicking slice phantoms.

Quantitative anatomy mimicking slice phantoms.
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DOI:
10.1002/mrm.28740
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发表时间:
2021-08
影响因子:
3.3
通讯作者:
Lustig M
Lustig M
中科院分区:
医学3区
文献类型:
--
作者:
Gopalan K;Tamir JI;Arias AC;Lustig M

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提出一种可重复的方法,用于构建具有目标 T1 和 T2 对比度的解剖模拟体模,用于定量磁共振成像。我们提出了一种可重复的方法来创建高分辨率、定量的切片模型。使用具有不同浓度 NiCl2 和 MnCl2 的凝胶创建模型,以实现目标 T1 和 T2 值。我们描述了一种精确定位解剖学上真实的松弛对的校准方法。此外,我们还开发了一种通过在亚克力板上挤压 3D 打印墙来制造切片模型的方法。这些程序结合起来创建了 Brainweb 数字模型的物理模拟。通过我们的方法,我们能够以小于 10% 的误差定位特定的 T1/T2 值。此外,我们的切片模型看起来很逼真,因为它们的几何形状源自解剖数据。用于跨序列、平台和不同成像位点验证新技术的标准化和准确的工具非常重要。用我们的程序设计的模拟解剖、多对比模型可用于评估、测试和验证基于模型的方法。
To present a reproducible methodology for building an anatomy mimicking phantom with targeted T1 and T2 contrast for use in quantitative magnetic resonance imaging. We propose a reproducible method for creating high-resolution, quantitative slice phantoms. The phantoms are created using gels with different concentrations of NiCl2 and MnCl2 to achieve targeted T1 and T2 values. We describe a calibration method for accurately targeting anatomically realistic relaxation pairs. In addition, we developed a method of fabricating slice phantoms by extruding 3D printed walls on acrylic sheets. These procedures are combined to create a physical analog of the Brainweb digital phantom. With our method, we are able to target specific T1/T2 values with less than 10% error. Additionally, our slice phantoms look realistic since their geometries are derived from anatomical data. Standardized and accurate tools for validating new techniques across sequences, platforms, and different imaging sites are important. Anatomy mimicking, multi-contrast phantoms designed with our procedures could be used for evaluating, testing, and verifying model-based methods.
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