Metabolic Syndrome and the Risk of Breast Cancer and Subtypes by Race, Menopause and BMI.
Metabolic Syndrome and the Risk of Breast Cancer and Subtypes by Race, Menopause and BMI.
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代谢综合征以及种族，更年期和BMI的乳腺癌和亚型的风险。
DOI：
10.3390/cancers10090299
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发表时间：
2018-09-01
期刊：
影响因子：
5.2
通讯作者：
Akinyemiju T
中科院分区：
文献类型：
--
作者：
Dibaba DT;Braithwaite D;Akinyemiju T
本研究的目的是探讨代谢综合征（MetS）与浸润性乳腺癌风险和分子亚型之间的关系，包括种族、更年期和体重指数（BMI）组。我们在美国国立卫生研究院退休人员协会（NIH-AARP）饮食与健康研究的94,555名女性参与者中检查了代谢综合征及其组成部分与浸润性乳腺癌风险的关系，并将导管原位癌作为竞争风险考虑在内。采用Fine和Gray方法进行Cox比例风险回归，生成校正基线社会人口统计学、行为和临床协变量的风险比（HR）和95%置信区间（CI）。在平均14年的随访期间，5380名（5.7%）女性患上了乳腺癌。总体而言，与没有MetS的女性相比，基线时的MetS与乳腺癌风险增加13%相关（HR: 1.13, 95% CI: 1.00, 1.27）；在绝经后妇女中获得了类似的估计（HR: 1.14, 95% CI: 1.01, 1.29）。在正常体重、超重/肥胖以及雌激素受体阳性乳腺癌亚型的人群中，met与乳腺癌风险的轻微但不显著增加有关。在美国国立卫生研究院和美国退休人员协会的队列研究中，met与乳腺癌风险增加有关。需要进一步的研究来明确评估MetS与所有BMI水平的三阴性乳腺癌亚型之间的关系。
The objective of this study was to investigate the association of metabolic syndrome (MetS) with the risk of invasive breast cancer and molecular subtypes across race, menopause, and body mass index (BMI) groups. We examined the association of metabolic syndrome and its components with risk of invasive breast cancer among 94,555 female participants of the National Institute of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, accounting for ductal carcinoma in situ as a competing risk. Cox proportional hazard regression with the Fine and Gray method was used to generate hazard ratios (HR) and 95% confidence intervals (CI) adjusting for baseline sociodemographic, behavioral, and clinical covariates. During a mean follow-up of 14 years, 5380 (5.7%) women developed breast cancer. Overall, MetS at baseline was associated with a 13% increased risk of breast cancer compared to women without MetS (HR: 1.13, 95% CI: 1.00, 1.27); similar estimates were obtained among postmenopausal women (HR: 1.14, 95% CI: 1.01, 1.29). MetS was associated with a slight but non-significantly increased risk of breast cancer among those with both normal weight and overweight/obesity, and those with estrogen receptor positive breast cancer subtype. In the NIH-AARP cohort, MetS was associated with an increased risk of breast cancer. Further studies are needed to definitively evaluate the association of MetS with triple negative breast cancer subtypes across all levels of BMI.
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影响因子：
--
作者：
Assiri AM;Kamel HF;Hassanien MF
通讯作者：
Hassanien MF
影响因子：
16.2
作者：
Esposito K;Chiodini P;Colao A;Lenzi A;Giugliano D
通讯作者：
Giugliano D
影响因子：
3.7
作者：
Agnoli C;Grioni S;Sieri S;Sacerdote C;Ricceri F;Tumino R;Frasca G;Pala V;Mattiello A;Chiodini P;Iacoviello L;De Curtis A;Panico S;Krogh V
通讯作者：
Krogh V
DOI：
10.1016/j.numecd.2009.02.006
发表时间：
2010-01
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
通讯作者：
Krogh V
DOI：
10.1158/1055-9965.epi-09-0235
发表时间：
2009-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kabat GC;Kim M;Chlebowski RT;Khandekar J;Ko MG;McTiernan A;Neuhouser ML;Parker DR;Shikany JM;Stefanick ML;Thomson CA;Rohan TE
通讯作者：
Rohan TE