Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study.
Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study.
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DOI：
10.1007/s10552-012-9916-y
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发表时间：
2012-04
影响因子：
2.3
通讯作者：
Olopade, Olufunmilayo I.
中科院分区：
文献类型：
--
作者：
Ogundiran, Temidayo O.;Huo, Dezheng;Adenipekun, Adeniyi;Campbell, Oladapo;Oyesegun, Rasaaq;Akang, Effiong;Adebamowo, Clement;Olopade, Olufunmilayo I.
整体肥胖和乳腺癌风险之间的关系已经得到了很好的认识，但中心性肥胖在乳腺癌发展中的作用尚不确定。在1998年至2009年期间，1233例浸润性乳腺癌病例和1101例社区对照被招募到尼日利亚伊巴丹的尼日利亚乳腺癌研究中。Logistic回归用于计算多变量比值比（OR）和95%置信区间（CI），调整年龄，体重指数（BMI）和其他已知的乳腺癌危险因素。腰围最高四分位数组相对于最低四分位数组的OR为2.39（95% CI：1.59-3.60; P趋势<0.001）。比较腰臀比（WHR）在最低四分位数组的女性，最高四分位数组女性的OR为2.15（95%CI：1.61-2.85; P趋势<0.001）。观察到臀围与乳腺癌之间呈负相关，最高四分位数的OR为0.36（95%CI：0.24-0.55; P趋势<0.001）。这三项措施的效果存在于绝经前和绝经后的妇女。值得注意的是，我们发现WHR和BMI之间存在显著的相互作用（P-相互作用=0.016）：BMI<25 kg/m2的女性的最高WHR四分位数与最低WHR四分位数比较的OR为2.81（95% CI：1.90-4.16），BMI ≥25 kg/m2的女性为1.70（95% CI：1.11-2.61）。这些结果表明，中心性肥胖，腰围和腰臀比测量，是一个重要的危险因素乳腺癌在尼日利亚妇女，和中心性肥胖的影响是强大的正常体重的妇女。
The relationship between overall obesity and breast cancer risk has been well recognized, but the role of central obesity in breast cancer development is uncertain. Between 1998 and 2009, 1233 invasive breast cancer cases and 1101 community controls were recruited into the Nigerian Breast Cancer Study at Ibadan, Nigeria. Logistic regressions were used to calculate multivariate odds ratio (OR) and 95% confidence intervals (CI), adjusting for age, body mass index (BMI), and other known risk factors for breast cancer. The OR for the highest quartile group of waist circumference relative to the lowest was 2.39 (95% CI: 1.59–3.60; P-trend<0.001). Comparing women with waist-hip ratio (WHR) in the lowest quartile group, the OR for women in the highest quartile category was 2.15 (95% CI: 1.61–2.85; P-trend<0.001). An inverse association was observed between hip circumference and breast cancer, with an OR of 0.36 for the highest quartile (95% CI: 0.24–0.55; P-trend<0.001). The effects of these three measures existed in both pre- and post-menopausal women. Of note, we found a significant interaction between WHR and BMI (P-interaction=0.016): the OR comparing the highest to lowest WHR quartile was 2.81 (95% CI: 1.90–4.16) for women with BMI<25 kg/m2 and 1.70 (95% CI: 1.11–2.61) for women with BMI ≥25 kg/m2. These results suggest that central adiposity, measured by waist circumference and waist-hip ratio, was an important risk factor for breast cancer in Nigerian women, and the effect of central adiposity was strong in normal weight women.
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影响因子：
8.8
作者：
Huo, D.;Adebamowo, C. A.;Ogundiran, T. O.;Akang, E. E.;Campbell, O.;Adenipekun, A.;Cummings, S.;Fackenthal, J.;Ademuyiwa, F.;Ahsan, H.;Olopade, O. I.
通讯作者：
Olopade, O. I.
影响因子：
12.7
作者：
Cooper, R;Rotimi, C;Wilks, R
通讯作者：
Wilks, R
影响因子：
2.3
作者：
Nemesure, Barbara;Wu, Suh-Yuh;Hennis, Anselm;Leske, M. Cristina
通讯作者：
Leske, M. Cristina
城市化尼日利亚妇女的腰围比和乳腺癌风险。
影响因子：
7.4
作者：
Adebamowo, CA;Ogundiran, TO;Adenipekun, AA;Oyesegun, RA;Campbell, OB;Akang, EE;Rotimi, CN;Olopade, OI
通讯作者：
Olopade, OI
影响因子：
6.4
作者：
Nemesure, Barbara;Wu, Suh-Yuh;Hennis, Anselm J.
通讯作者：
Hennis, Anselm J.