Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country.
Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country.
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DOI：
10.1186/1471-2458-4-9
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发表时间：
2004-03-25
影响因子：
4.5
通讯作者：
Burnier M
中科院分区：
文献类型：
--
作者：
Conen D;Wietlisbach V;Bovet P;Shamlaye C;Riesen W;Paccaud F;Burnier M
在发展中国家，很少有人调查高尿酸血症的流行情况。本研究的目的是在一个平均血压较高的发展中国家(塞舌尔、印度洋，主要是非洲裔人口)调查高尿酸血症的患病率以及尿酸水平与各种心血管危险因素之间的关系。这项横断面健康检查调查是根据塞舌尔的人口随机抽样进行的。研究对象为1011名年龄在25岁至之间的受试者。测量血压(BP)、体重指数(BMI)、腰围、腰臀比、总胆固醇和高密度脂蛋白(HDLc)、血清甘油三酯和血尿酸。使用散点图平滑技术和特定性别的线性回归模型对数据进行分析。男性血清尿酸水平&420μ摩尔/L的患病率为35.2%，女性血尿酸水平&360μ摩尔/L的患病率为8.7%。血尿酸与血清甘油三酯在男性和女性之间都有很强的相关性(男性r=0.73，女性r=0.59，p<；0.001)。尿酸水平也与年龄、BMI、血压、酒精和降压治疗的使用显著相关，但程度较小。在回归模型中，甘油三酯、年龄、体重指数、抗高血压治疗和饮酒约占男性和女性血清尿酸变化的50%(R2)。这项研究表明，在塞舌尔这样的发展中国家，高尿酸血症的患病率可能很高。除了饮酒和抗高血压治疗(主要是利尿剂)的使用外，血清尿酸与代谢综合征的参数显著相关，特别是血清甘油三酯。考虑到肥胖和代谢综合征在全世界的发病率不断上升，以及高尿酸血症和心血管并发症之间的潜在联系，应该更加重视发展中国家高尿酸血症患病率的变化。
The prevalence of hyperuricemia has rarely been investigated in developing countries. The purpose of the present study was to investigate the prevalence of hyperuricemia and the association between uric acid levels and the various cardiovascular risk factors in a developing country with high average blood pressures (the Seychelles, Indian Ocean, population mainly of African origin). This cross-sectional health examination survey was based on a population random sample from the Seychelles. It included 1011 subjects aged 25 to 64 years. Blood pressure (BP), body mass index (BMI), waist circumference, waist-to-hip ratio, total and HDL cholesterol, serum triglycerides and serum uric acid were measured. Data were analyzed using scatterplot smoothing techniques and gender-specific linear regression models. The prevalence of a serum uric acid level >420 μmol/L in men was 35.2% and the prevalence of a serum uric acid level >360 μmol/L was 8.7% in women. Serum uric acid was strongly related to serum triglycerides in men as well as in women (r = 0.73 in men and r = 0.59 in women, p < 0.001). Uric acid levels were also significantly associated but to a lesser degree with age, BMI, blood pressure, alcohol and the use of antihypertensive therapy. In a regression model, triglycerides, age, BMI, antihypertensive therapy and alcohol consumption accounted for about 50% (R2) of the serum uric acid variations in men as well as in women. This study shows that the prevalence of hyperuricemia can be high in a developing country such as the Seychelles. Besides alcohol consumption and the use of antihypertensive therapy, mainly diuretics, serum uric acid is markedly associated with parameters of the metabolic syndrome, in particular serum triglycerides. Considering the growing incidence of obesity and metabolic syndrome worldwide and the potential link between hyperuricemia and cardiovascular complications, more emphasis should be put on the evolving prevalence of hyperuricemia in developing countries.
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影响因子：
5
作者：
BRAND, FN;MCGEE, DL;CASTELLI, WP
通讯作者：
CASTELLI, WP
影响因子：
158.5
作者：
CANNON, PJ;STASON, WB;LARAGH, JH
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LARAGH, JH
影响因子：
120.7
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Fang, J;Alderman, MH
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Alderman, MH
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影响因子：
5
作者：
LEE, J;SPARROW, D;WEISS, ST
通讯作者：
WEISS, ST
影响因子：
8.3
作者：
Lehto, S;Niskanen, L;Laakso, M
通讯作者：
Laakso, M