Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.
Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.
复制标题
婚姻分居后的心理困扰与血清素转运蛋白基因的多态性相互作用,可在实验室中预测心脏迷走神经控制。
DOI:
10.1111/psyp.12409
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发表时间:
2015
期刊:
影响因子:
3.7
通讯作者:
Moreno,FranciscoA
中科院分区:
文献类型:
--
作者:
Hasselmo,Karen;Sbarra,DavidA;O'Connor,Mary-Frances;Moreno,FranciscoA
Marital separation is linked to negative mental and physical health; however, the strength of this link may vary across people. This study examined changes in respiratory sinus arrhythmia (RSA), used to assess cardiac vagal control, in recently separated adults (N= 79;Mtime since separation = 3.5 months). When reflecting on the separation, self‐reported psychological distress following the separation interacted with a polymorphism in the serotonin transporter gene (5‐HTTLPR) and a relevant single nucleotide polymorphism (SNP), rs25531, to predict RSA. Among people reporting emotional difficulties after the separation, those who were homozygous for the short allele had lower RSA levels while reflecting on their relationship than other genotypes. The findings, although limited by the relatively small sample size, are discussed in terms of how higher‐sensitivity genotypes may interact with psychological responses to stress to alter physiology.
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