Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.

Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.
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婚姻分居后的心理困扰与血清素转运蛋白基因的多态性相互作用,可在实验室中预测心脏迷走神经控制。

DOI:
10.1111/psyp.12409
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发表时间:
2015
期刊:
影响因子:
3.7
通讯作者:
Moreno,FranciscoA
Moreno,FranciscoA
中科院分区:
心理学3区
文献类型:
--
作者:
Hasselmo,Karen;Sbarra,DavidA;O'Connor,Mary-Frances;Moreno,FranciscoA

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婚姻分离与消极的心理和身体健康有关;然而,这种联系的强度可能因人而异。本研究检查了最近分离的成人(N= 79; M分离时间= 3.5个月)呼吸性窦性心律失常(RSA)的变化,用于评估心脏迷走神经控制。当反思分离时,分离后自我报告的心理困扰与5-羟色胺转运蛋白基因(5-HTTLPR)的多态性和相关的单核苷酸多态性(SNP)rs 25531相互作用,以预测RSA。在分离后报告情绪困难的人中,那些短等位基因纯合子的人在反映他们的关系时比其他基因型的RSA水平更低。研究结果虽然受到样本量相对较小的限制,但在更高敏感性的基因型如何与对压力的心理反应相互作用以改变生理方面进行了讨论。
Marital separation is linked to negative mental and physical health; however, the strength of this link may vary across people. This study examined changes in respiratory sinus arrhythmia (RSA), used to assess cardiac vagal control, in recently separated adults (N= 79;Mtime since separation = 3.5 months). When reflecting on the separation, self‐reported psychological distress following the separation interacted with a polymorphism in the serotonin transporter gene (5‐HTTLPR) and a relevant single nucleotide polymorphism (SNP), rs25531, to predict RSA. Among people reporting emotional difficulties after the separation, those who were homozygous for the short allele had lower RSA levels while reflecting on their relationship than other genotypes. The findings, although limited by the relatively small sample size, are discussed in terms of how higher‐sensitivity genotypes may interact with psychological responses to stress to alter physiology.
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