Changed salt appetite and central angiotensin II-induced cellular activation in rat offspring following hypoxia during fetal stages.
Changed salt appetite and central angiotensin II-induced cellular activation in rat offspring following hypoxia during fetal stages.
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胎儿期缺氧后大鼠后代盐食欲的变化和中枢血管紧张素 II 诱导的细胞激活
DOI：
10.1016/j.peptides.2010.03.009
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发表时间：
2010-06
期刊：
影响因子：
3
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Yang W;Mao C;Xia F;Zheng J;Wang A;Zhu L;He R;Xu Z
妊娠期缺氧可导致胎儿生长受限，并导致发育过程中的功能异常。本研究旨在探讨胎儿期缺氧对子代大鼠中枢血管紧张素（Ang）网络相关的致渴行为的长期影响。妊娠期间缺氧导致胎儿血液pO 2和体重下降，随后出现产后“追赶”生长。皮下注射高渗盐水或脑室内注射血管紧张素II显著增加了出生前暴露于缺氧的后代的盐摄入量，而两组之间的水摄入量相同。Ang II诱导的c-fos表达在室旁核、正中视前核、视上核和穹隆下器中检测到，与产前暴露于缺氧的后代中前脑AT 2受体蛋白丰度降低相关。两组之间的中央AT 1受体蛋白水平没有变化。妊娠期缺氧可能与以后生活中体液调节行为功能障碍相关的发育问题有关，与中枢血管紧张素II介导的神经激活和脑中血管紧张素II受体表达的变化相关。
Hypoxia in pregnancy may induce fetal growth restriction and cause functional abnormalities during development. The present study determined the long-term influence of hypoxia in fetal life on dipsogenic behavior linked to central angiotensin (Ang) network in the offspring rats. Fetal blood pO2 and body weight were decreased by hypoxia during pregnancy, followed by a postnatal “catch-up” growth. Subcutaneous hypertonic saline or intracerebroventricular Ang II significantly increased salt intake in the offspring prenatally exposed to hypoxia, while water intake was the same between the two groups. Ang II-induced c-fos expression was detected in the paraventricular nuclei, median preoptic nuclei, supraoptic nuclei, and subfornical organ in the brain, in association with reduced forebrain AT2 receptor protein abundance in the offspring prenatally exposed to hypoxia. Levels of central AT1 receptor protein were not changed between the two groups. Hypoxia during pregnancy could be linked to developmental problems related to behavioral dysfunctions in body fluid regulations in later life, in association with the change in central angiotensin II-mediated neural activation and expression of the Ang II receptor in the brain.
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影响因子：
4.1
作者：
Xu F;Mao C;Hu Y;Rui C;Xu Z;Zhang L
通讯作者：
Zhang L
影响因子：
6.7
作者：
Mao C;Shi L;Xu F;Zhang L;Xu Z
通讯作者：
Xu Z
影响因子：
4.1
作者：
Xu F;Mao C;Liu Y;Wu L;Xu Z;Zhang L
通讯作者：
Zhang L
影响因子：
3.3
作者：
MAHON, JM;ALLEN, M;FITZSIMONS, JT
通讯作者：
FITZSIMONS, JT
影响因子：
2.5
作者：
Shi, LJ;Mao, CP;Xu, Z
通讯作者：
Xu, Z