Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California.
Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California.
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DOI：
10.1289/ehp.0901292
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发表时间：
2010-10
影响因子：
10.4
通讯作者：
Tager IB
中科院分区：
文献类型：
--
作者：
Mann JK;Balmes JR;Bruckner TA;Mortimer KM;Margolis HG;Pratt B;Hammond SK;Lurmann FW;Tager IB
尽管研究表明空气污染与哮喘儿童的哮喘症状恶化有关，但人们对亚组的易感性知之甚少，特别是那些有特应性的亚组。这项研究旨在评估我们的先验假设，即可识别的哮喘儿童亚群更有可能因暴露于环境空气污染而出现喘息。在美国加利福尼亚州弗雷斯诺招募了 315 名 6-11 岁哮喘儿童进行纵向随访。在基线访视期间，对儿童进行了呼吸道症状调查问卷和过敏原皮肤点刺试验。参与者每年三次完成为期 14 天的小组讨论，在此期间他们每天回答两次症状问题。中央监测站的环境空气质量数据用于分配以下污染物的暴露量：空气动力学直径≤2.5μm的颗粒物、空气动力学直径在2.5至10μm之间的颗粒物（PM10-2.5）、元素碳、二氧化氮（NO2）、硝酸盐和O3。对于整个组来说，喘息与短期暴露于 NO2 显着相关[优势比 (OR) = 1.10，增加 8.7 ppb； 95% 置信区间 (CI)，1.02–1.20] 和 PM10–2.5（OR = 1.11，增加 14.7-μg/m3；95% CI，1.01–1.22）。对于猫或常见真菌皮肤测试呈阳性的儿童以及患有轻度间歇性哮喘的男孩来说，这两种污染物与喘息的相关性更强。与交通排放相关的污染物 NO2 和具有生物活性成分的污染物 PM10-2.5 与居住在加利福尼亚州弗雷斯诺的哮喘儿童喘息风险增加有关。对猫或常见真菌过敏的儿童和患有轻度间歇性哮喘的男孩是我们观察到最大关联的亚组。
Although studies have demonstrated that air pollution is associated with exacerbation of asthma symptoms in children with asthma, little is known about the susceptibility of subgroups, particularly those with atopy. This study was designed to evaluate our a priori hypothesis that identifiable subgroups of asthmatic children are more likely to wheeze with exposure to ambient air pollution. A cohort of 315 children with asthma, 6–11 years of age, was recruited for longitudinal follow-up in Fresno, California (USA). During the baseline visit, children were administered a respiratory symptom questionnaire and allergen skin-prick test. Three times a year, participants completed 14-day panels during which they answered symptom questions twice daily. Ambient air quality data from a central monitoring station were used to assign exposures to the following pollutants: particulate matter ≤ 2.5 μm in aerodynamic diameter, particulate matter between 2.5 and 10 μm in aerodynamic diameter (PM10–2.5), elemental carbon, nitrogen dioxide (NO2), nitrate, and O3. For the group as a whole, wheeze was significantly associated with short-term exposures to NO2 [odds ratio (OR) = 1.10 for 8.7-ppb increase; 95% confidence interval (CI), 1.02–1.20] and PM10–2.5 (OR = 1.11 for 14.7-μg/m3 increase; 95% CI, 1.01–1.22). The association with wheeze was stronger for these two pollutants in children who were skin-test positive to cat or common fungi and in boys with mild intermittent asthma. A pollutant associated with traffic emissions, NO2, and a pollutant with bioactive constituents, PM10–2.5, were associated with increased risk of wheeze in asthmatic children living in Fresno, California. Children with atopy to cat or common fungi and boys with mild intermittent asthma were the subgroups for which we observed the largest associations.
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哮喘儿童室内和室外生成的颗粒的肺作用。
影响因子：
10.4
作者：
通讯作者：
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影响因子：
24.3
作者：
Just, J;Ségala, C;Neukirch, F
通讯作者：
Neukirch, F
DOI：
10.1164/ajrccm.162.5.9908113
发表时间：
2000-11-01
影响因子：
24.7
作者：
Mortimer, KM;Tager, IB;Redline, S
通讯作者：
Redline, S
影响因子：
10.4
作者：
McConnell, R;Berhane, K;Peters, JM
通讯作者：
Peters, JM
影响因子：
11.4
作者：
Miguel, AG;Cass, GR;Weiss, J
通讯作者：
Weiss, J