Zinc-metal-organic frameworks with tunable UV diffuse-reflectance as sunscreens.
Zinc-metal-organic frameworks with tunable UV diffuse-reflectance as sunscreens.
复制标题
具有可调紫外线漫反射率的锌金属有机框架作为防晒剂
DOI：
10.1186/s12951-022-01292-1
复制
发表时间：
2022-02-19
影响因子：
10.2
通讯作者：
Duan X
中科院分区：
文献类型：
--
作者：
Xiao J;Li H;Zhao W;Cai C;You T;Wang Z;Wang M;Zeng F;Cheng J;Li J;Duan X
紫外线暴露继续引发许多健康问题，尽管商业防晒霜是可以买到的。人们迫切需要安全、高效的新型紫外线滤光器。金属有机骨架(MOF)通过精确控制合成，具有可调谐的光学、电学和光电性质，可作为紫外光滤光片开发的平台。本论文选择了四种不同带隙能的锌基MOF，研究了它们的光学行为，并评价了它们作为防晒剂的可能性。研究发现，沸石咪唑骨架-8(ZIF-8)具有最高和最宽的紫外线反射率，从而保护小鼠皮肤免受晒伤和DNA损伤，甚至达到与猪皮肤上商用紫外线过滤器(二氧化钛或氧化锌)相当或更高的抗紫外线功效，这一模型与人类皮肤非常相关。此外，ZIF-8还具有低自由基产生、低皮肤渗透率、低毒性、高透明度和高稳定性的特点，适用于局部皮肤使用。这些结果证实了ZIF-8可能是一种安全有效的人体防晒替代品，而MOFS可能是开发更有效、更安全的紫外线过滤器的新来源。网上版载有补充材料，可在10.1186/s12951-022-01292-1查阅。
UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel UV filters with high safety and efficacy are urgently needed. Metal–organic frameworks (MOFs) could be a suitable platform for UV filter development, due to their tunable optical, electrical, and photoelectric properties by precise controlled synthesis. Herein, four zinc-based MOFs with various bandgap energies were chose to investigate their optical behaviors and evaluate their possibility as sunscreens. Zeolitic imidazolate framework-8 (ZIF-8) was found to possess the highest and widest UV reflectance, thereby protecting against sunburn and DNA damage on mouse skin and even achieving a comparable or higher anti-UV efficacy relative to the commercially available UV filters, TiO2 or ZnO, on pig skin, a model that correlates well with human skin. Also, ZIF-8 exerted appealing characteristics for topical skin use with low radical production, low skin penetration, low toxicity, high transparency, and high stability. These results confirmed ZIF-8 could potentially be a safe and effective sunscreen surrogate for human, and MOFs could be a novel source to develop more effective and safe UV filters. The online version contains supplementary material available at 10.1186/s12951-022-01292-1.
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DOI：
10.1126/science.1253735
发表时间：
2014-11-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lo JA;Fisher DE
通讯作者：
Fisher DE
影响因子：
3.9
作者：
Kong, Song-Zhi;Li, Dong-Dong;Li, Si-Dong
通讯作者：
Li, Si-Dong
影响因子：
19
作者：
Hunter-Sellars, Elwin;Saenz-Cavazos, Paola A.;Williams, Daryl R.
通讯作者：
Williams, Daryl R.
影响因子：
3.3
作者：
Kuc, A.;Enyashin, A.;Seifert, G.
通讯作者：
Seifert, G.
DOI：
10.1016/j.jphotobiol.2016.06.026
发表时间：
2016-09-01
影响因子：
5.4
作者：
Marto, J.;Gouveia, L. F.;Ribeiro, H. M.
通讯作者：
Ribeiro, H. M.