Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke.
Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke.
复制标题
出血性中风后脑血流自动调节的神经血管机制
DOI：
10.1155/2017/5819514
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发表时间：
2017
影响因子：
3.1
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Xiao M;Li Q;Feng H;Zhang L;Chen Y
在出血性中风的初期，包括脑出血和蛛网膜下腔出血，反射机制被激活以保护脑灌注，但继发性脑血流自动调节功能障碍最终会减少整体脑血流量和代谢底物的输送，导致全身脑缺血、缺氧，最终导致神经元细胞受损。 死亡。脑血流受多种调节机制控制，包括当前动脉压、颅内压、动脉血气、神经活动和代谢需求。受血管神经网络概念的启发，所揭示的神经血管机制越来越受到人们的关注。星形胶质细胞、神经元、周细胞、内皮细胞等形成一个通讯网络，相互调节以及脑血流。然而，负责这些新参与者和血管之间这种通讯的信号分子尚未得到明确证实。最近的证据表明转录机制（包括但不限于miRNA、lncRNA、外泌体等）对于脑血流自动调节发挥着关键作用。在本综述中，我们试图总结脑卒中易发状态和出血性脑卒中后的血流动力学变化，并强调脑血流自动调节的神经血管机制，希望为出血性脑卒中的病理生理学和治疗策略提供更系统和创新的研究兴趣。
During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral perfusion, but secondary dysfunction of cerebral flow autoregulation will eventually reduce global cerebral blood flow and the delivery of metabolic substrates, leading to generalized cerebral ischemia, hypoxia, and ultimately, neuronal cell death. Cerebral blood flow is controlled by various regulatory mechanisms, including prevailing arterial pressure, intracranial pressure, arterial blood gases, neural activity, and metabolic demand. Evoked by the concept of vascular neural network, the unveiled neural vascular mechanism gains more and more attentions. Astrocyte, neuron, pericyte, endothelium, and so forth are formed as a communicate network to regulate with each other as well as the cerebral blood flow. However, the signaling molecules responsible for this communication between these new players and blood vessels are yet to be definitively confirmed. Recent evidence suggested the pivotal role of transcriptional mechanism, including but not limited to miRNA, lncRNA, exosome, and so forth, for the cerebral blood flow autoregulation. In the present review, we sought to summarize the hemodynamic changes and underline neural vascular mechanism for cerebral blood flow autoregulation in stroke-prone state and after hemorrhagic stroke and hopefully provide more systematic and innovative research interests for the pathophysiology and therapeutic strategies of hemorrhagic stroke.
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