Lifetime personal cigarette smoking and risk of young-onset breast cancer by subtype among non-Hispanic Black and White women in the Young Women's Health History Study.
Lifetime personal cigarette smoking and risk of young-onset breast cancer by subtype among non-Hispanic Black and White women in the Young Women's Health History Study.
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DOI：
10.1007/s10549-022-06675-4
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发表时间：
2022-10
影响因子：
3.8
通讯作者：
Velie, Ellen M.
中科院分区：
文献类型：
--
作者：
Ihenacho, Ugonna;Hamilton, Ann S.;Mack, Wendy J.;Wu, Anna H.;Unger, Jennifer B.;Pathak, Dorothy R.;Hirko, Kelly A.;Houang, Richard T.;Press, Michael F.;Schwartz, Kendra L.;Marcus, Lydia R.;Velie, Ellen M.
关键词：
评估终身个人吸烟与乳腺癌（YOBC;诊断<50岁）总体风险和乳腺癌（BC）亚型风险之间的关联，以及风险是否因种族或社会经济地位（SEP）而异。数据来自年轻女性健康史研究（YWHHS），这是一项基于人群的病例对照研究，研究对象为洛杉矶县和底特律大都会监测、流行病学和最终结果（SEER）登记区20-49岁的非西班牙裔黑人（NHB）和白色（NHW）女性（n= 1，812例，n= 1，381例对照），2010-2015年。采用样本加权、多变量校正的多分类logistic回归分析，对终生个人吸烟特征和不同亚型的YOBC风险进行了研究。与曾经吸烟和从不吸烟相关的YOBC风险因亚型而异（P异质性=0.01），管腔A型（校正比值比[aOR] 1.34; 95%置信区间[CI] 1.06-1.68）和HER 2型（aOR 1.97; 95% CI 1.23-3.16）的风险显著增加，与管腔B或三阴性亚型无关。此外，开始吸烟≥30年（与从不吸烟相比）与管腔A（aOR 1.55; 95% CI 1.07-2.26）和HER 2型YOBC（aOR 2.77; 95% CI 1.32-5.79）风险增加具有统计学显著性相关，但与其他亚型无关。此外，在经产妇女中，首次足月妊娠前开始吸烟（与从未吸烟相比）与管腔A型YOBC风险增加显著相关（aOR 1.45; 95% CI 1.11-1.89）。我们几乎没有观察到种族和SEP相互作用的证据。研究结果证实了先前的报告吸烟和管腔A型YOBC之间的正相关性，并确定了吸烟和HER 2型YOBC之间的新关联。
To evaluate the association between lifetime personal cigarette smoking and young-onset breast cancer (YOBC; diagnosed <50 years of age) risk overall and by breast cancer (BC) subtype, and whether risk varies by race or socioeconomic position (SEP). Data are from the Young Women’s Health History Study (YWHHS), a population-based case-control study of non-Hispanic Black (NHB) and White (NHW) women, ages 20–49 years (n=1,812 cases, n=1,381 controls) in the Los Angeles County and Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) registry areas, 2010–2015. Lifetime personal cigarette smoking characteristics and YOBC risk by subtype were examined using sample-weighted, multivariable-adjusted polytomous logistic regression. YOBC risk associated with ever versus never smoking differed by subtype (Pheterogeneity=0.01) with risk significantly increased for Luminal A (adjusted odds ratio [aOR] 1.34; 95% confidence interval [CI] 1.06–1.68) and HER2-type (aOR 1.97; 95% CI 1.23–3.16), and no association with Luminal B or Triple Negative subtypes. Additionally, ≥30 years since smoking initiation (versus never) was statistically significantly associated with an increased risk of Luminal A (aOR 1.55; 95% CI 1.07–2.26) and HER2-type YOBC (aOR 2.77; 95% CI 1.32–5.79), but not other subtypes. Also, among parous women, smoking initiated before first full-term pregnancy (versus never) was significantly associated with an increased risk of Luminal A YOBC (aOR 1.45; 95% CI 1.11–1.89). We observed little evidence for interactions by race and SEP. Findings confirm prior reports of a positive association between cigarette smoking and Luminal A YOBC and identify a novel association between smoking and HER2-type YOBC.
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DOI：
10.1186/bcr3429
发表时间：
2013-06-27
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Danforth DN Jr
通讯作者：
Danforth DN Jr
影响因子：
3.8
作者：
Ellingjord-Dale, Merete;Vosl, Linda;Ursin, Giske
通讯作者：
Ursin, Giske
影响因子：
2.3
作者：
Andaya, Abegail A.;Enewold, Lindsey;Zhu, Kangmin
通讯作者：
Zhu, Kangmin
成人目前吸烟 - 美国，2016年。
DOI：
10.15585/mmwr.mm6702a1
发表时间：
2018-01-19
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Jamal A;Phillips E;Gentzke AS;Homa DM;Babb SD;King BA;Neff LJ
通讯作者：
Neff LJ
影响因子：
4.5
作者：
Graff-Iversen, Sidsel;Hewitt, Stephen;Ariansen, Inger
通讯作者：
Ariansen, Inger