It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder.
It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder.
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DOI：
10.1038/mp.2014.185
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发表时间：
2015-02
影响因子：
11
通讯作者：
Zubieta, J-K
中科院分区：
文献类型：
--
作者：
Hsu, D. T.;Sanford, B. J.;Meyers, K. K.;Love, T. M.;Hazlett, K. E.;Walker, S. J.;Mickey, B. J.;Koeppe, R. A.;Langenecker, S. A.;Zubieta, J-K
The μ-opioid receptor (MOR) system, well known for dampening physical pain, is also hypothesized to dampen “social pain.” We used positron emission tomography scanning with the selective MOR radioligand [11C]carfentanil to test the hypothesis that MOR system activation in response to social rejection and acceptance is altered in medication-free patients diagnosed with current major depressive disorder (MDD, n = 17) compared to healthy controls (HCs, n = 18). During rejection, MDD patients showed reduced MOR activation (e.g., reduced endogenous opioid release) in brain regions regulating stress, mood, and motivation, and slower emotional recovery compared to HCs. During acceptance, only HCs showed increased social motivation, which was positively correlated with MOR activation in the nucleus accumbens, a reward structure. Abnormal MOR function in MDD may hinder emotional recovery from negative social interactions and decrease pleasure derived from positive interactions. Both effects may reinforce depression, trigger relapse, and contribute to poor treatment outcomes.
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影响因子：
7.4
作者：
Horner, Michelle S.;Siegle, Greg J.;Schwartz, Robert M.;Price, Rebecca B.;Haggerty, Agnes E.;Collier, Amanda;Friedman, Edward S.
通讯作者：
Friedman, Edward S.
影响因子：
3.7
作者：
Kalin, NH;Shelton, SE;Lynn, DE
通讯作者：
Lynn, DE
影响因子：
3.6
作者：
BEATTY, WW;COSTELLO, KB
通讯作者：
COSTELLO, KB
影响因子：
--
作者：
Danese, Andrea;Moffitt, Terrie E.;Harrington, HonaLee;Milne, Barry J.;Polanczyk, Guilherme;Pariante, Carmine M.;Poulton, Richie;Caspi, Avshalom
通讯作者：
Caspi, Avshalom
影响因子：
3
作者：
Hsu DT;Kirouac GJ;Zubieta JK;Bhatnagar S
通讯作者：
Bhatnagar S