Short sleep duration and the risk of nonalcoholic fatty liver disease/metabolic associated fatty liver disease: a systematic review and meta-analysis.
Short sleep duration and the risk of nonalcoholic fatty liver disease/metabolic associated fatty liver disease: a systematic review and meta-analysis.
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睡眠时间短与非酒精性脂肪肝/代谢相关脂肪肝的风险：系统评价和荟萃分析
DOI：
10.1007/s11325-022-02767-z
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发表时间：
2023-10
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
目前尚不清楚非酒精性脂肪性肝病(NAFLD)/代谢功能障碍相关脂肪性肝病（MAFLD）是否与睡眠时间短有关。进行了一项荟萃分析以确定睡眠时间不足是否会增加NAFLD/MAFLD的风险。对Embase、PubMed和Cochrane图书馆数据库从成立到2022年8月1日进行了全面系统的文献综述。研究包括检查睡眠时间不足与NAFLD/MAFLD风险之间的相关性。我们使用随机效应模型合并了比值比（ORs）和95%置信区间（ci）。这项荟萃分析包括15项研究，共涉及261554名参与者。在合并分析中，发现短睡眠时间与NAFLD/MAFLD风险增加密切相关（OR, 1.15; 95% CI, 1.04-1.28; P = 0.01），研究间存在中等程度的异质性（I2 = 71.92%, Q = 49.87, P < 0.01）。敏感性分析表明，主要结局是稳健的，没有显著的发表偏倚。这项荟萃分析表明，睡眠时间不足与NAFLD/MAFLD风险升高密切相关。研究结果表明，获得充足的睡眠可能有助于预防NAFLD/MAFLD，鉴于药物治疗的低反应率，这一点尤为重要。在线版本包含补充材料，可在10.1007/s11325-022-02767-z获得。
It is unclear whether or not nonalcoholic fatty liver disease (NAFLD)/metabolic dysfunction–associated fatty liver disease (MAFLD) is related to short sleep duration. A meta-analysis was conducted to determine if inadequate sleep time increased the risk of NAFLD/MAFLD. A comprehensive systematic literature review was conducted in the Embase, PubMed, and Cochrane Library databases from inception to August 1, 2022. Studies examining the correlation between inadequate sleep time and the risk of NAFLD/MAFLD were included. We pooled the odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. This meta-analysis included fifteen studies involving a total of 261,554 participants. In the pooled analysis, short sleep duration was found to be strongly correlated with an increased risk of NAFLD/MAFLD (OR, 1.15; 95% CI, 1.04–1.28; P = 0.01), with a moderate degree of heterogeneity between studies (I2 = 71.92%, Q = 49.87, P < 0.01). The sensitivity analysis suggested that the primary outcome was robust, and there was no significant publication bias. This meta-analysis indicates that inadequate sleep duration is strongly correlated with an elevated risk of NAFLD/MAFLD. The findings suggest that obtaining an adequate amount of sleep may be useful for preventing NAFLD/MAFLD, which is especially important given the low rate of response to pharmacotherapy. The online version contains supplementary material available at 10.1007/s11325-022-02767-z.
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