Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth.
Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth.
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DOI：
10.3390/ijerph14070731
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发表时间：
2017-07-06
影响因子：
--
通讯作者：
Liu D
中科院分区：
文献类型：
--
作者：
Mendola P;Ha S;Pollack AZ;Zhu Y;Seeni I;Kim SS;Sherman S;Liu D
对死产与慢性和急性空气污染的关系进行了研究，结果不一致。我们对来自美国12个临床研究中心的223，375例单胎分娩的回顾性队列研究了死产风险。平均标准的空气污染物暴露计算使用修改后的社区多尺度空气质量模型的交付日和前七天，整个怀孕，和头三个月。Poisson回归模型使用广义估计方程估计死产的相对危险度（RR）和95%置信区间（CI）与四分位数范围增加的污染物与温度，临床和人口因素的调整。在单一污染物模型中，臭氧（O3）与分娩前第2、3和5-7天死产风险增加13-22%相关，这些结果在多污染物模型中持续第5天（RR = 1.22，CI = 1.07-1.38）和第6天（RR = 1.18，CI = 1.04-1.33）。在单一污染物模型中，整个妊娠期和头三个月的O3增加了18-39%的风险。母亲哮喘增加死产风险与慢性PM2.5和一氧化碳暴露有关。慢性和急性O3暴露持续增加死胎风险，而其他污染物的作用各不相同。在美国，每年大约有8000例死产可归因于O3暴露。
Chronic and acute air pollution has been studied in relation to stillbirth with inconsistent findings. We examined stillbirth risk in a retrospective cohort of 223,375 singleton deliveries from 12 clinical sites across the United States. Average criteria air pollutant exposure was calculated using modified Community Multiscale Air Quality models for the day of delivery and each of the seven days prior, whole pregnancy, and first trimester. Poisson regression models using generalized estimating equations estimated the relative risk (RR) of stillbirth and 95% confidence intervals (CI) in relation to an interquartile range increase in pollutant with adjustment for temperature, clinical, and demographic factors. Ozone (O3) was associated with a 13–22% increased risk of stillbirth on days 2, 3, and 5–7 prior to delivery in single pollutant models, and these findings persisted in multi-pollutant models for days 5 (RR = 1.22, CI = 1.07–1.38) and 6 (RR = 1.18, CI = 1.04–1.33). Whole pregnancy and first trimester O3 increased risk 18–39% in single pollutant models. Maternal asthma increased stillbirth risk associated with chronic PM2.5 and carbon monoxide exposures. Both chronic and acute O3 exposure consistently increased stillbirth risk, while the role of other pollutants varied. Approximately 8000 stillbirths per year in the US may be attributable to O3 exposure.
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影响因子：
168.9
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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DOI：
10.1136/bmj.h4620
发表时间：
2015-09-23
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
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通讯作者：
Colbourn T