Enhancing the repeatability and sensitivity of low-cost PCB, pH-sensitive field-effect transistors.
Enhancing the repeatability and sensitivity of low-cost PCB, pH-sensitive field-effect transistors.
复制标题
增强低成本 PCB、pH 敏感场效应晶体管的可重复性和灵敏度。
DOI：
10.1016/j.bios.2023.115150
复制
发表时间：
2023
影响因子：
12.6
通讯作者：
Ashton R
中科院分区：
文献类型：
--
作者：
Ashton R
在印刷电路板（PCB）上制造的分立式扩展栅极pH敏感场效应晶体管（dEGFET）是一种低成本、易于制造的分析技术，可应用于广泛的应用。电沉积氧化铱（IrOx）膜由于其理论上高的pH敏感性和容易沉积而成为有前景的pH敏感层，但通常表现出低pH敏感性或缺乏再现性。此外，迄今为止，组合的IrOx和dEGFET PCB系统尚未实现。在这项研究中，我们展示了一个dEGFET pH传感器的基础上，通过电沉积IrOx膜，可以可靠地和可重复地显示超越能斯特pH响应呈现pH敏感的PCB上制造的扩展栅极。使用互补的表面分析技术的组合，我们表明，dEGFET的高pH值的灵敏度和可重复性是依赖于两个化学成分和关键的IrOx膜的均匀性。可以通过在电沉积之前电化学抛光延伸的栅电极来增强IrOx膜的均匀性，导致dEGFET表现出70.7 ± 5 mV/pH（n = 56）的中值pH敏感性，相比之下，电沉积在未抛光的PCB电极上的IrOx仅为31.3 ± 14 mV/pH（n = 31）。最后，我们通过展示由于β-内酰胺酶活性而对氨苄青霉素的检测和定量来展示这些设备的适用性，从而为廉价且无处不在的传感器奠定基础，这些传感器可应用于医疗保健和环境监测的一系列全球挑战。
Discrete, extended gate pH-sensitive field-effect transistors (dEGFETs) fabricated on printed circuit boards (PCBs) are a low-cost, simple to manufacture analytical technology that can be applied to a wide range of applications. Electrodeposited iridium oxide (IrOx) films have emerged as promising pH-sensitive layers owing to their theoretically high pH sensitivity and facile deposition, but typically exhibit low pH sensitivity or lack reproducibility. Moreover, to date, a combined IrOx and dEGFET PCB system has not yet been realised. In this study, we demonstrate a dEGFET pH sensor based on an extended gate manufactured on PCB that is rendered pH sensitive through an electrodeposited IrOx film, which can reliably and repeatably display beyond-Nernstian pH response. Using a combination of complementary surface analysis techniques, we show that the high pH sensitivity and repeatability of the dEGFETs are dependent on both the chemical composition and critically the uniformity of the IrOx film. The IrOx film uniformity can be enhanced through electrochemical polishing of the extended gate electrode prior to electrodeposition, leading to dEGFETs that exhibit a median pH sensitivity of 70.7 ± 5 mV/pH (n = 56) compared to only 31.3 ± 14 mV/pH (n = 31) for IrOx electrodeposited on non-polished PCB electrodes. Finally, we demonstrate the applicability of these devices by demonstrating the detection and quantification of ampicillin due toβ-Lactamase enzyme activity, thus laying the foundation for cheap and ubiquitous sensors which can be applied to a range of global challenges across healthcare and environmental monitoring.
登录
查看更多内容
无漂移能恩斯特氧化铱 pH 传感器
DOI：
10.1109/sensor.1997.635491
发表时间：
1997
期刊：
Proceedings of International Solid State Sensors and Actuators Conference (Transducers '97)
影响因子：
--
作者：
J. Hendrikse;W. Olthuis;P. Bergveld
通讯作者：
P. Bergveld
影响因子：
4.9
作者：
MEYERS, BR;WILKINSON, P;HIRSCHMAN, SZ
通讯作者：
HIRSCHMAN, SZ
一种内置参比电极的新型 pH 微传感器
影响因子：
0.6
作者：
Young;Young;B. Sohn;Jung;Chang
通讯作者：
Chang
影响因子：
8.9
作者：
Kaisti, Matti;Boeva, Zhanna;Levon, Kalle
通讯作者：
Levon, Kalle
Britton-Robinson 缓冲水溶液中 Cu(II) 还原的 pH 依赖性的电化学研究
影响因子：
1.5
作者：
A. A. Shaikh;J. Firdaws;Badrunnessa, S. Serajee;M. Rahman;P. K. Bakshi
通讯作者：
P. K. Bakshi