Frontal cortex and the discovery of abstract action rules.

Frontal cortex and the discovery of abstract action rules.
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DOI:
10.1016/j.neuron.2010.03.025
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发表时间:
2010-04-29
期刊:
影响因子:
16.2
通讯作者:
D'Esposito, Mark
D'Esposito, Mark
中科院分区:
医学1区
文献类型:
--
作者:
Badre, David;Kayser, Andrew S.;D'Esposito, Mark

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虽然我们经常遇到我们以前没有经验的情况,但我们很快就学会了如何在这些新情况下表现。这种适应性行为依赖于可概括的抽象行为规则,而不是将特定线索映射到特定反应的具体规则。虽然人们知道额叶皮层支持具体规则的学习,但对支持抽象规则习得的神经机制却知之甚少。在这里,我们使用一种新的强化学习范式来证明沿额叶皮层的上尾轴更多的前部区域支持更高抽象水平的规则学习。此外,这些结果表明,当人类面临新的规则学习问题时,这种直立-尾端分工支持在多个抽象层次上同时寻找上下文和行为之间的关系。
Although we often encounter circumstances with which we have no prior experience, we rapidly learn how to behave in these novel situations. Such adaptive behavior relies on abstract behavioral rules that are generalizable, rather than concrete rules mapping specific cues to specific responses. Though the frontal cortex is known to support concrete rule learning, less well understood are the neural mechanisms supporting the acquisition of abstract rules. Here we use a novel reinforcement learning paradigm to demonstrate that more anterior regions along the rostro-caudal axis of frontal cortex support rule learning at higher levels of abstraction. Moreover, these results indicate that when humans confront new rule learning problems, this rostro-caudal division of labor supports the search for relationships between context and action at multiple levels of abstraction simultaneously.
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