A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina.
A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina.
复制标题
DOI：
10.1016/j.ajog.2012.10.888
复制
发表时间：
2013-02
影响因子：
9.8
通讯作者：
Hollis, Bruce W.
中科院分区：
文献类型：
--
作者：
Wagner, Carol L.;McNeil, Rebecca;Hamilton, Stuart A.;Winkler, Joyce;Cook, Carolina Rodriguez;Warner, Gloria;Bivens, Betty;Davis, Deborah J.;Smith, Pamela G.;Murphy, Martha;Shary, Judy R.;Hollis, Bruce W.
确定怀孕期间每天 4000 IU 维生素 D3（对比 2000 IU/天）是否安全，并以剂量依赖性方式改善孕产妇/新生儿 25(OH)D。 257 名妊娠 12-16 周的孕妇被纳入研究。在 2000 IU/天磨合一个月后，随机分为 2000- 与 4000 IU/天。监测参与者的高钙尿症、高钙血症和 25(OH)D 状态。 2000 IU 组和 4000 IU 组的母亲 25(OH)D (n=161) 从基线时的 22.7(SD 9.7) 分别增加到 36.2(SD 15) 和 37.9(SD 13.5)。虽然孕产妇 25(OH)D 相对于基线的变化在各组之间没有差异，但 25(OH)D 每月增加在各组之间存在差异 (p<0.01)。没有发生与补充剂相关的不良事件。 2000 年的平均脐带血 25(OH)D (ng/mL) 为 22.1±10.3，4000 IU 组为 27.0±13.3 (p=0.024)。在控制种族和研究地点后，早产和分娩与预产期和平均 25(OH)D 呈负相关，但与基线 25(OH)D 无关。孕期母亲每天补充 2000 和 4000 IU 维生素 D 可改善孕产妇/新生儿维生素 D 状况。感染、早产和早产风险降低的证据具有启发性，需要针对这些终点进行更多研究。
To determine whether 4000 IU vitamin D3/day (vs. 2000 IU/day) during pregnancy is safe and improves maternal/neonatal 25(OH)D in a dose-dependent manner. 257 pregnant women 12–16 weeks’ gestation were enrolled. Randomization to 2000- vs. 4000 IU/day followed one-month run-in at 2000 IU/day. Participants were monitored for hypercalciuria, hypercalcemia and 25(OH)D status. Maternal 25(OH)D (n=161) increased from 22.7(SD 9.7) at baseline to 36.2(SD 15) and 37.9(SD 13.5) in the 2000- and 4000 IU groups, respectively. While maternal 25(OH)D change from baseline did not differ between groups, 25(OH)D monthly increase differed between groups (p<0.01). No supplementation-related adverse events occurred. Mean cord blood 25(OH)D (ng/mL) was 22.1±10.3 in 2000- and 27.0±13.3 in 4000 IU group (p=0.024). After controlling for race and study site, preterm birth and labor were inversely associated with pre-delivery- and mean 25(OH)D, but not baseline 25(OH)D,. Maternal supplementation with 2000 and 4000 IU vitamin D/day during pregnancy improved maternal/neonatal vitamin D status. Evidence of risk reduction in infection, preterm labor and preterm birth was suggestive, requiring additional studies powered for these endpoints.
登录
查看更多内容
影响因子：
8.4
作者：
De-Regil, Luz Maria;Palacios, Cristina;Ansary, Ali;Kulier, Regina;Pena-Rosas, Juan Pablo
通讯作者：
Pena-Rosas, Juan Pablo
影响因子：
6.2
作者：
Grant, WB
通讯作者：
Grant, WB
影响因子：
5.1
作者：
GARLAND, FC;GARLAND, CF;YOUNG, JF
通讯作者：
YOUNG, JF
影响因子：
4.2
作者：
Bodnar, Lisa M.;Catov, Janet M.;Simhan, Hyagriv N.
通讯作者：
Simhan, Hyagriv N.
影响因子：
105.7
作者：
BROOKE, OG;BROWN, IRF;WINDER, SM
通讯作者：
WINDER, SM