Opposite modulation of brain functional networks implicated at low vs. high demand of attention and working memory.
Opposite modulation of brain functional networks implicated at low vs. high demand of attention and working memory.
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DOI：
10.1371/journal.pone.0087078
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Potenza MN
中科院分区：
文献类型：
--
作者：
Xu J;Calhoun VD;Pearlson GD;Potenza MN
功能磁共振成像（fMRI）研究表明，大脑在静息状态或任务执行期间将其活动组织成多个功能网络（FN）。然而，这些FN的功能尚未完全理解。为了研究这些FN的操作，空间独立成分分析（sICA）被用来提取FN从fMRI数据采集健康参与者执行视觉任务，两个级别的注意力和工作记忆负荷。任务相关的调制提取FN进行了评估。一组FN在低负荷条件下表现出增加的活性，在高负荷条件下表现出降低的活性。这些FN共同涉及左外侧额顶叶皮层、前额叶皮层和腹内侧前额叶皮层。第二组FN在高负荷条件下表现出增加的活性，在低负荷条件下表现出降低的活性。这些FN共同涉及顶内沟、额叶视野、外侧额顶叶皮质、额叶皮层和双侧背侧前扣带回。虽然这两组功能神经元表现出相反的任务相关调制，但它们在外侧和内侧额顶叶皮层和额叶皮层广泛重叠。使用标准的基于一般线性模型的分析不太可能揭示FN的这种重叠。通过评估任务相关的调制，本研究区分重叠FN的功能作用。包括左额顶叶网络在内的几个FN涉及低注意力负荷的任务条件，而包括背侧注意力网络在内的另一组FN涉及高注意力需求的任务条件。
Functional magnetic resonance imaging (fMRI) studies indicate that the brain organizes its activity into multiple functional networks (FNs) during either resting condition or task-performance. However, the functions of these FNs are not fully understood yet. To investigate the operation of these FNs, spatial independent component analysis (sICA) was used to extract FNs from fMRI data acquired from healthy participants performing a visual task with two levels of attention and working memory load. The task-related modulations of extracted FNs were assessed. A group of FNs showed increased activity at low-load conditions and reduced activity at high-load conditions. These FNs together involve the left lateral frontoparietal cortex, insula, and ventromedial prefrontal cortex. A second group of FNs showed increased activity at high-load conditions and reduced activity at low-load conditions. These FNs together involve the intraparietal sulcus, frontal eye field, lateral frontoparietal cortex, insula, and dorsal anterior cingulate, bilaterally. Though the two groups of FNs showed opposite task-related modulations, they overlapped extensively at both the lateral and medial frontoparietal cortex and insula. Such an overlap of FNs would not likely be revealed using standard general-linear-model-based analyses. By assessing task-related modulations, this study differentiated the functional roles of overlapping FNs. Several FNs including the left frontoparietal network are implicated in task conditions of low attentional load, while another set of FNs including the dorsal attentional network is implicated in task conditions involving high attentional demands.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
25
作者：
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
Smith, SM
影响因子：
5.7
作者：
Domagalik, Aleksandra;Beldzik, Ewa;Marek, Tadeusz
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Marek, Tadeusz
影响因子：
17.6
作者：
Calhoun VD;Adalı T
通讯作者：
Adalı T