Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression.
Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression.
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DOI：
10.1016/j.jpsychires.2017.11.005
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Taylor WD
中科院分区：
文献类型：
--
作者：
Abi Zeid Daou M;Boyd BD;Donahue MJ;Albert K;Taylor WD
血管病变在老年抑郁症中很常见，导致大脑功能的变化。我们研究了晚年抑郁是否与脑血流量(CBF)的差异有关，以及这种差异是否与血管风险和脑血管病理，特别是脑白质高强度(WMH)体积有关。23名抑郁症老年人和20名年龄和性别匹配、无精神病史的老年人完成了颅脑3T磁共振成像。MRI程序包括在室内空气中和在高二氧化碳状态下采集的伪连续动脉自旋标记(PCASL)，以计算脑血管反应性(CVR)。脑分割确定了计算CBF和CVR的额叶、颞叶、顶叶和扣带亚区。抑郁组CBF呈前后梯度，额叶CBF较低，顶叶、颞叶、丘脑和海马区CBF较高。在扣带回皮质也观察到类似的前后部梯度，前部显示较低的CBF，而后部显示较高的CBF。我们没有观察到两组在CVR测量上的任何差异。我们没有观察到CBF和CVR与血管风险或WMH容量之间的显著关系，除了一个孤立的发现，即在嘴前扣带回皮质，WMH容量较高与CBF较低。老年抑郁症患者前部脑血流量减少可能反映了这些区域代谢活动的减少，而后部脑血流量增加可能代表代偿过程或后部固有功能网络的不同活动。未来的工作应该研究这些发现如何与随着年龄增长而发生的代偿性变化有关。
Vascular pathology is common in late-life depression, contributing to changes in cerebral function. We examined whether late-life depression was associated with differences in cerebral blood flow (CBF) and whether such differences were related to vascular risk and cerebrovascular pathology, specifically white matter hyperintensity (WMH) volumes. Twenty-three depressed elders and 20 age- and sex-matched elders with no psychiatric history completed cranial 3T MRI. MRI procedures included a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition obtained while on room air and during a hypercapnia challenge allowing for calculation of cerebrovascular reactivity (CVR). Brain segmentation identified frontal, temporal, parietal and cingulate sub-regions in which CBF and CVR were calculated. The depressed group exhibited an anterior-posterior gradient in CBF, with lower CBF throughout the frontal lobe but higher CBF in the parietal lobe, temporal lobe, thalamus and hippocampus. A similar anterior to posterior gradient was observed in the cingulate cortex, with anterior regions exhibiting lower CBF and posterior regions exhibiting higher CBF. We did not observe any group differences in CVR measures. We did not observe significant relationships between CBF and CVR with vascular risk or WMH volumes, aside from an isolated finding associating higher WMH volumes with lower CBF in the rostral anterior cingulate cortex. Decreased anterior CBF in depressed elders might reflect decreased metabolic activity in these regions, while increased posterior CBF may represent either compensatory processes or different activity of posterior intrinsic functional networks. Future work should examine how these findings are related to compensatory changes with aging.
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DOI：
10.1176/appi.ajp.2011.10060853
发表时间：
2011-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Aizenstein HJ;Andreescu C;Edelman KL;Cochran JL;Price J;Butters MA;Karp J;Patel M;Reynolds CF 3rd
通讯作者：
Reynolds CF 3rd
影响因子：
10.5
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
通讯作者：
O'Brien, John T.
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
4.8
作者：
de Castro, A. Gomez-Carrillo;Bajbouj, M.;Neu, P.
通讯作者：
Neu, P.
影响因子：
3.3
作者：
Neu, P;Schlattmann, P;Hartmann, A
通讯作者：
Hartmann, A