Exhaled breath condensate pH does not discriminate asymptomatic gastroesophageal reflux or the response to lansoprazole treatment in children with poorly controlled asthma.
Exhaled breath condensate pH does not discriminate asymptomatic gastroesophageal reflux or the response to lansoprazole treatment in children with poorly controlled asthma.
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呼出气冷凝物 pH 值不能区分无症状胃食管反流或哮喘控制不佳的儿童对兰索拉唑治疗的反应。
DOI：
10.1016/j.jaip.2014.04.006
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
AmericanLungAssociation'sAsthmaClinicalResearchCentersNetwork
中科院分区：
文献类型：
--
作者：
Fitzpatrick,AnneM;Holbrook,JanetT;Wei,ChristineY;Brown,MeredithS;Wise,RobertA;Teague,WGerald;AmericanLungAssociation'sAsthmaClinicalResearchCentersNetwork
尽管呼气冷凝水（EBC） pH值已被确定为哮喘临床试验中感兴趣的“新兴”生物标志物，但EBC pH值的临床决定因素仍然知之甚少。其他研究将胃酸反流引起的呼吸道症状（例如咳嗽）与EBC的短暂酸化联系起来。目的：我们试图确定一个高度特征性的控制不良哮喘儿童样本中EBC酸化的临床和生理相关性。我们假设：(1)通过24小时食管pH监测确定无症状胃食管反流的儿童EBC pH值低于无胃食管反流的儿童，(2)兰索拉唑治疗会改变这些儿童的EBC pH值，(3)EBC酸化与哮喘症状增加、哮喘控制和生活质量较差以及呼吸氮氧化物（NOx）形成增加有关。方法纳入《哮喘儿童胃酸反流研究》（NCT00442013）中哮喘控制和食管pH值数据较差的儿童110例，年龄6 ~ 17岁。在随机分组和研究第8、16和24周时，儿童提交EBC样本进行pH和NOx测量。结果连续的EBC pH测量不能区分无症状胃食管反流，与呼吸NOx形成无关。在基线和整个研究期间，EBC pH值也没有区分哮喘特征，如药物和保健利用、肺功能、哮喘控制和生活质量。结论尽管EBC的采集相对容易，但EBC pH作为一种生物标志物并不能为参加哮喘临床试验的哮喘儿童提供有用的信息。
BackgroundAlthough exhaled breath condensate (EBC) pH has been identified as an “emerging” biomarker of interest for asthma clinical trials, the clinical determinants of EBC pH remain poorly understood. Other studies have associated acid reflux–induced respiratory symptoms, for example, cough, with transient acidification of EBC.ObjectiveWe sought to determine the clinical and physiologic correlates of EBC acidification in a highly characterized sample of children with poorly controlled asthma. We hypothesized that (1) children with asymptomatic gastroesophageal reflux determined by 24-hour esophageal pH monitoring would have a lower EBC pH than children without gastroesophageal reflux, (2) treatment with lansoprazole would alter EBC pH in those children, and (3) EBC acidification would be associated with increased asthma symptoms, poorer asthma control and quality of life, and increased formation of breath nitrogen oxides (NOx).MethodsA total of 110 children, age range 6 to 17 years, with poor asthma control and esophageal pH data enrolled in the Study of Acid Reflux in Children with Asthma (NCT00442013) were included. Children submitted EBC samples for pH and NOx measurement at randomization and at study weeks 8, 16, and 24.ResultsSerial EBC pH measurements failed to distinguish asymptomatic gastroesophageal reflux and was not associated with breath NOx formation. EBC pH also did not discriminate asthma characteristics such as medication and health care utilization, pulmonary function, and asthma control and quality of life both at baseline and across the study period.ConclusionDespite the relative ease of EBC collection, EBC pH as a biomarker does not provide useful information of children with asthma who were enrolled in asthma clinical trials.
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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