Diagnosis of the metabolic syndrome is associated with disproportionately high levels of high-sensitivity C-reactive protein in non-Hispanic black adolescents: an analysis of NHANES 1999-2008.
Diagnosis of the metabolic syndrome is associated with disproportionately high levels of high-sensitivity C-reactive protein in non-Hispanic black adolescents: an analysis of NHANES 1999-2008.
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DOI：
10.2337/dc10-1877
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发表时间：
2011-03
期刊：
影响因子：
16.2
通讯作者：
Sumner AE
中科院分区：
文献类型：
--
作者：
DeBoer MD;Gurka MJ;Sumner AE
众所周知，代谢综合征（MetS）在非西班牙裔黑人青少年中的患病率低于非西班牙裔白人或西班牙裔青少年，但不同种族/民族的代谢综合征相对严重程度尚不清楚。高敏c反应蛋白（hsCRP）表明，炎症是将MetS与心血管疾病和2型糖尿病联系起来的关键因素。我们的目的是确定在met青少年中hsCRP的升高是否因种族/民族而异。我们使用国家健康和营养调查（1999-2008），并评估青少年（12-19岁）使用儿科/青少年适应ATP III定义的MetS。我们使用线性回归来评估met状态和种族与hsCRP浓度之间的相互作用。对于男性和女性青少年，与没有MetS的青少年相比，MetS与hsCRP水平升高有关。然而，非西班牙裔黑人与非西班牙裔白人相比，有和没有MetS的青少年中hsCRP的升高更大（P = 0.04），但西班牙裔没有（P = 0.18）。在所有种族中，hsCRP浓度与个体MetS成分的相关性相似。在对被诊断为MetS的青少年的评估中，非西班牙裔黑人的BMI和高血压高于其他种族，但MetS的特征没有其他种族/民族差异。非西班牙裔黑人青少年的hsCRP差异大于非西班牙裔白人的差异，而不是西班牙裔青少年的差异。因此，尽管MetS在非西班牙裔黑人中的患病率较低，但MetS在非西班牙裔黑人青少年中是一个特别好的炎症指标。
Whereas it is known that the metabolic syndrome (MetS) has a paradoxically lower prevalence in non–Hispanic black adolescents than in non–Hispanic whites or Hispanics, the relative severity of MetS by race/ethnicity is unknown. Inflammation, indicated by high-sensitivity C-reactive protein (hsCRP), is a key factor linking MetS to cardiovascular disease and type 2 diabetes. Our goal was to determine whether elevations of hsCRP vary by race/ethnicity among adolescents with MetS. We used the National Health and Nutrition Examination Survey (1999–2008) and evaluated adolescents (age 12–19 years) using a pediatric/adolescent adaptation of the ATP III definition of MetS. We used linear regression to evaluate the interaction between MetS status and ethnicity with respect to hsCRP concentration. For male and female adolescents, MetS was associated with elevated hsCRP levels compared with adolescents without MetS. However, the elevation in hsCRP between adolescents with and without MetS was greater in non–Hispanic blacks compared with that in non–Hispanic whites (P = 0.04) but not that in Hispanics (P = 0.18). hsCRP concentrations correlated with individual MetS components similarly among all ethnicities. In an evaluation of adolescents diagnosed with MetS, non–Hispanic blacks had higher BMI and more hypertension than other ethnicities but there were no other racial/ethnic differences in the features of MetS. Non–Hispanic black adolescents have a greater differential in hsCRP between those with and those without MetS than the differential in non–Hispanic whites but not that in Hispanics. Therefore, even though MetS has a low prevalence in non–Hispanic blacks, MetS is a particularly good indicator of inflammation in non–Hispanic black adolescents.
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影响因子：
37.8
作者：
Dekker, JM;Girman, C;Heine, RJ
通讯作者：
Heine, RJ
影响因子：
16.2
作者：
Lee, S;Bacha, F;Arslanian, SA
通讯作者：
Arslanian, SA
影响因子：
5.1
作者：
Morrison, John A.;Friedman, Lisa Aronson;Glueck, Charles J.
通讯作者：
Glueck, Charles J.
影响因子：
5.3
作者：
Sumner, Anne E.;Cowie, Catherine C.
通讯作者：
Cowie, Catherine C.
影响因子：
7.7
作者：
Gower, BA;Nagy, TR;Goran, MI
通讯作者：
Goran, MI