Adolescent substance use in the multimodal treatment study of attention-deficit/hyperactivity disorder (ADHD) (MTA) as a function of childhood ADHD, random assignment to childhood treatments, and subsequent medication.
Adolescent substance use in the multimodal treatment study of attention-deficit/hyperactivity disorder (ADHD) (MTA) as a function of childhood ADHD, random assignment to childhood treatments, and subsequent medication.
复制标题
DOI：
10.1016/j.jaac.2012.12.014
复制
发表时间：
2013-03
影响因子：
13.3
通讯作者：
MTA Cooperative Group
中科院分区：
文献类型：
--
作者：
Molina BS;Hinshaw SP;Eugene Arnold L;Swanson JM;Pelham WE;Hechtman L;Hoza B;Epstein JN;Wigal T;Abikoff HB;Greenhill LL;Jensen PS;Wells KC;Vitiello B;Gibbons RD;Howard A;Houck PR;Hur K;Lu B;Marcus S;MTA Cooperative Group
旨在确定注意力缺陷/多动症儿童多中心多模式治疗研究 (MTA；n=436) 中随机分配的 14 个月治疗对物质使用和物质使用障碍 (SUD) 的长期影响，直至儿童入组后 8 年；测试 (a) 随访时的药物治疗，(b) 随着时间的推移累积的精神兴奋剂治疗，或 (c) 两者是否与物质使用/SUD 相关；将 ADHD 样本中的物质使用/SUD 与非 ADHD 童年同学对照组进行比较 (n=261)。除重要的累积兴奋剂治疗问题外，所有测试均使用具有计划对比的混合效应回归模型，该问题使用倾向评分匹配分析。最初的随机治疗组在 8 年或更早的随访中（M 年龄 = 17 岁）在物质使用/SUD 方面没有显着差异。随访时的药物（主要是兴奋剂）和累积的兴奋剂治疗均与青少年物质使用/SUD 无关。无论性别如何，ADHD 样本在所有时间点的物质使用（包括使用两种或多种物质和 SUD）均高于非 ADHD 样本。无论是作为儿童期的随机治疗分配、随访时的药物治疗，还是从儿童期开始的 8 年随访中的累积刺激治疗进行分析，治疗 ADHD 的药物都不能防止或增加青春期物质使用或 SUD 的明显风险。这些结果表明，需要为患有多动症的男孩和女孩确定以青少年为中心的替代或辅助药物滥用预防和治疗方法，特别是考虑到他们使用和滥用多种药物的风险增加，而兴奋剂药物无法改善这种风险。临床试验注册信息——注意力缺陷多动障碍（MTA）儿童多模式治疗研究； http://clinical Trials.gov/； NCT00000388。
To determine long-term effects on substance use and substance use disorder (SUD), up to 8 years after childhood enrollment, of the randomly assigned 14-month treatments in the multisite Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA; n=436); to test whether (a) medication at follow-up, (b) cumulative psychostimulant treatment over time, or (c) both relate to substance use/SUD; to compare substance use/SUD in the ADHD sample to the non-ADHD childhood classmate comparison group (n=261). Mixed-effects regression models with planned contrasts were used for all tests except the important cumulative stimulant treatment question, for which propensity score matching analysis was used. The originally randomized treatment groups did not differ significantly on substance use/SUD by the 8 year follow-up or earlier (M age = 17 years). Neither medication at follow-up (mostly stimulants) nor cumulative stimulant treatment was associated with adolescent substance use/SUD. Substance use at all time points, including use of two or more substances and SUD, were each greater in the ADHD than non-ADHD samples, regardless of sex. Medication for ADHD did not protect from, nor contribute to, visible risk of substance use or SUD by adolescence, whether analyzed as randomized treatment assignment in childhood, as medication at follow-up, or as cumulative stimulant treatment over an 8 year follow-up from childhood. These results suggest the need to identify alternative or adjunctive adolescent-focused approaches to substance abuse prevention and treatment for boys and girls with ADHD, especially given their increased risk for use and abuse of multiple substances that is not improved with stimulant medication. Clinical trial registration information—Multimodal Treatment Study of Children with Attention Deficit and Hyperactivity Disorder (MTA); http://clinical trials.gov/; NCT00000388.
登录
查看更多内容
影响因子：
5.5
作者：
Crean RD;Crane NA;Mason BJ
通讯作者：
Mason BJ
DOI：
10.1001/archpediatrics.2010.180
发表时间：
2010-10-01
影响因子：
--
作者：
Brook, David W.;Brook, Judith S.;Koppel, Jonathan
通讯作者：
Koppel, Jonathan
影响因子：
6.4
作者：
Faraone, Stephen V.;Buitelaar, Jan
通讯作者：
Buitelaar, Jan
影响因子：
8
作者：
Biederman, J;Wilens, T;Faraone, SV
通讯作者：
Faraone, SV
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL