Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections.
Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections.
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DOI：
10.1186/1475-2875-3-33
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发表时间：
2004-09-14
期刊：
影响因子：
3
通讯作者：
Read AF
中科院分区：
文献类型：
--
作者：
de Roode JC;Culleton R;Bell AS;Read AF
疟疾感染通常具有遗传多样性，可能导致共感染菌株之间的竞争。这种竞争对于耐药性的传播至关重要。使用啮齿动物疟疾恰鲍迪疟原虫研究了药物治疗对宿主内竞争的影响。小鼠同时感染耐药克隆和药物敏感克隆，然后接受药物治疗或不治疗。通过将小鼠喂食史氏按蚊来评估传播情况。在没有药物的情况下，敏感克隆竞争性抑制耐药克隆；这导致无性寄生虫密度降低，也减少了向蚊媒的传播。然而，药物治疗允许抗性克隆填补因去除敏感克隆而空出的生态空间，使其能够像在没有竞争的情况下一样传播。这些结果表明，在药物压力下，耐药菌株具有两个优势：（1）它们比敏感菌株存活得更好；（2）它们可以利用消除竞争对手所带来的机会。当混合感染常见时，这种影响可能会增加耐药性的传播。
Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance. The effects of drug treatment on within-host competition were studied using the rodent malaria Plasmodium chabaudi. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were then either drug-treated or left untreated. Transmission was assessed by feeding mice to Anopheles stephensi mosquitoes. In the absence of drugs, the sensitive clone competitively suppressed the resistant clone; this resulted in lower asexual parasite densities and also reduced transmission to the mosquito vector. Drug treatment, however, allowed the resistant clone to fill the ecological space emptied by the removal of the sensitive clone, allowing it to transmit as well as it would have done in the absence of competition. These results show that under drug pressure, resistant strains can have two advantages: (1) they survive better than sensitive strains and (2) they can exploit the opportunities presented by the removal of their competitors. When mixed infections are common, such effects could increase the spread of drug resistance.
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DOI：
10.1016/s0035-9203(99)90324-3
发表时间：
1999-02-01
影响因子：
2.2
作者：
Felger, I;Smith, T;Beck, HP
通讯作者：
Beck, HP
DOI：
10.1016/s0035-9203(99)90322-x
发表时间：
1999-02-01
影响因子：
2.2
作者：
Smith, T;Beck, HP;Tanner, M
通讯作者：
Tanner, M
DOI：
10.1098/rspb.2002.2241
发表时间：
2003-03-07
影响因子：
4.7
作者：
White, NJ;Pongtavornpinyo, W
通讯作者：
Pongtavornpinyo, W
影响因子：
4
作者：
Talisuna, AO;Langi, P;D'Alessandro, U
通讯作者：
D'Alessandro, U
影响因子：
2.4
作者：
SNOUNOU, G;BOURNE, T;BROWN, KN
通讯作者：
BROWN, KN