Nutrition intervention for migraine: a randomized crossover trial.
Nutrition intervention for migraine: a randomized crossover trial.
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DOI：
10.1186/1129-2377-15-69
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发表时间：
2014-10-23
期刊：
影响因子：
--
通讯作者：
Barnard ND
中科院分区：
文献类型：
--
作者：
Bunner AE;Agarwal U;Gonzales JF;Valente F;Barnard ND
有限的证据表明，饮食干预可能为偏头痛提供了一种有希望的方法。这项研究的目的是确定低脂肪植物性饮食干预对偏头痛严重程度和频率的影响。从华盛顿特区的普通社区招募了42名成年偏头痛患者，并随机分为两组。这项为期36周的交叉研究包括两种治疗方法：饮食指导和安慰剂补充剂。每个疗程为16周，其间有4周的冲刷。在饮食期间，低脂肪素食饮食处方为期4周，之后使用排除饮食。参与者在每个阶段的开始、中期和结束时进行评估。使用学生的t检验来确定有无意义。最后两周最严重的头痛，根据视觉模拟评分，最初为6.4/10厘米(SD 2.1厘米)，在节食期和补充期分别下降了2.1厘米和0.7厘米(p=0.03)。平均头痛强度(0-10分)最初为每周4.2(SD 1.4)，在饮食期间下降了1.0，在补充期间下降了0.5(p=0.20)。平均头痛频率最初为每周2.3次(SD 1.8)，在饮食期间下降了0.3次，在补充期间下降了0.4次(p=0.61)。患者对变化的总体印象显示，在饮食期间疼痛有更大的改善(p<；0.001)。这些结果表明，营养方法可能是偏头痛治疗的有用部分，但方法学问题需要进一步研究。ClinicalTrials.gov、NCT01699009和NCT01547494。
Limited evidence suggests that dietary interventions may offer a promising approach for migraine. The purpose of this study was to determine the effects of a low-fat plant-based diet intervention on migraine severity and frequency. Forty-two adult migraine sufferers were recruited from the general community in Washington, DC, and divided randomly into two groups. This 36-week crossover study included two treatments: dietary instruction and placebo supplement. Each treatment period was 16 weeks, with a 4-week washout between. During the diet period, a low-fat vegan diet was prescribed for 4 weeks, after which an elimination diet was used. Participants were assessed at the beginning, midpoint, and end of each period. Significance was determined using student’s t-tests. Worst headache pain in last 2 weeks, as measured by visual analog scale, was initially 6.4/10 cm (SD 2.1 cm), and declined 2.1 cm during the diet period and 0.7 cm during the supplement period (p=0.03). Average headache intensity (0–10 scale) was initially 4.2 (SD 1.4) per week, and this declined by 1.0 during the diet period and by 0.5 during the supplement period (p=0.20). Average headache frequency was initially 2.3 (SD 1.8) per week, and this declined by 0.3 during the diet period and by 0.4 during the supplement period (p=0.61). The Patient’s Global Impression of Change showed greater improvement in pain during the diet period (p<0.001). These results suggest that a nutritional approach may be a useful part of migraine treatment, but that methodologic issues necessitate further research. Clinicaltrials.gov, NCT01699009 and NCT01547494.
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DOI：
10.1016/j.jaci.2010.10.007
发表时间：
2010-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
NIAID-Sponsored Expert Panel;Boyce JA;Assa'ad A;Burks AW;Jones SM;Sampson HA;Wood RA;Plaut M;Cooper SF;Fenton MJ;Arshad SH;Bahna SL;Beck LA;Byrd-Bredbenner C;Camargo CA Jr;Eichenfield L;Furuta GT;Hanifin JM;Jones C;Kraft M;Levy BD;Lieberman P;Luccioli S;McCall KM;Schneider LC;Simon RA;Simons FE;Teach SJ;Yawn BP;Schwaninger JM
通讯作者：
Schwaninger JM
影响因子：
5.4
作者：
Mitchell, Natasha;Hewitt, Catherine E.;Torgerson, David J.
通讯作者：
Torgerson, David J.
影响因子：
3
作者：
Ware, JE
通讯作者：
Ware, JE
影响因子：
1.4
作者：
Fukui, Patrícia Timy;Gonçalves, Tessa Rachel Tranquillini;Peres, Mario Fernando Prieto
通讯作者：
Peres, Mario Fernando Prieto
影响因子：
5.1
作者：
Verrotti, A.;Agostinelli, S.;Battistella, P. A.
通讯作者：
Battistella, P. A.