Amygdala perfusion is predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect.
Amygdala perfusion is predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect.
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DOI：
10.1371/journal.pone.0097466
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Holt DJ
中科院分区：
文献类型：
--
作者：
Coombs G 3rd;Loggia ML;Greve DN;Holt DJ
先前的研究表明，在经历临床和亚临床水平的焦虑和抑郁（负面情绪）的人中，杏仁核的活性升高。有人提出，这种关联的基础是前额叶皮层对杏仁核的抑制性输入减少，导致杏仁核过度活跃。先前的研究已经发现负面情绪与1）杏仁核过度活跃和2）杏仁核-前额连接减少之间的关系。然而，目前尚不清楚杏仁核活动的升高是否与消极情绪状态下杏仁核-前额连接的减少有关。在这里，我们使用静息态动脉自旋标记（ASL）和血氧水平依赖（BOLD）功能磁共振成像（fMRI）相结合来测试这个模型，测量活动（局部脑血流量，rCBF）和功能连接（BOLD信号的相关波动）杏仁核的一个亚区与前额叶皮层，基底外侧核（BLA），38名健康受试者的亚综合征焦虑水平。BLA rCBF与焦虑水平密切相关。此外，BLA rCBF和焦虑与BLA与尾侧腹内侧前额叶皮层的功能耦合强度呈负相关。最后，BLA灌注被认为是一个中介的BLA-前额叶连接和焦虑之间的关系。这些结果表明，BLA的灌注及其与前额叶皮层的功能耦合的测量直接指示健康受试者的焦虑水平，并且低的BLA-前额叶连接可能导致BLA活性增加并导致焦虑。因此，这些数据提供了一个经常引用的电路模型的负面影响，使用一种新的，多模式的成像方法的关键证据。
Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction in inhibitory input to the amygdala from the prefrontal cortex and resultant over-activity of the amygdala underlies this association. Prior studies have found relationships between negative affect and 1) amygdala over-activity and 2) reduced amygdala-prefrontal connectivity. However, it is not known whether elevated amygdala activity is associated with decreased amygdala-prefrontal connectivity during negative affect states. Here we used resting-state arterial spin labeling (ASL) and blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) in combination to test this model, measuring the activity (regional cerebral blood flow, rCBF) and functional connectivity (correlated fluctuations in the BOLD signal) of one subregion of the amygdala with strong connections with the prefrontal cortex, the basolateral nucleus (BLA), and subsyndromal anxiety levels in 38 healthy subjects. BLA rCBF was strongly correlated with anxiety levels. Moreover, both BLA rCBF and anxiety were inversely correlated with the strength of the functional coupling of the BLA with the caudal ventromedial prefrontal cortex. Lastly, BLA perfusion was found to be a mediator of the relationship between BLA-prefrontal connectivity and anxiety. These results show that both perfusion of the BLA and a measure of its functional coupling with the prefrontal cortex directly index anxiety levels in healthy subjects, and that low BLA-prefrontal connectivity may lead to increased BLA activity and resulting anxiety. Thus, these data provide key evidence for an often-cited circuitry model of negative affect, using a novel, multi-modal imaging approach.
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影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
1.7
作者：
Abercrombie, HC;Schaefer, SM;Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
7.8
作者：
Caci, H;Baylé, FH;Boyer, P
通讯作者：
Boyer, P
影响因子：
10.6
作者：
Cardoso de Almeida, Jorge Renner;Versace, Amelia;Mechelli, Andrea;Hassel, Stefanie;Quevedo, Karina;Kupfer, David Jerome;Phillips, Mary Louise
通讯作者：
Phillips, Mary Louise
影响因子：
2.9
作者：
DETRE, JA;ZHANG, WG;LEIGH, JS
通讯作者：
LEIGH, JS