Subsynovial connective tissue development in the rabbit carpal tunnel.
Subsynovial connective tissue development in the rabbit carpal tunnel.
复制标题
兔腕管滑膜下结缔组织的发育。
DOI：
10.1002/vms3.281
复制
发表时间：
2020-11
影响因子：
1.7
通讯作者：
Amadio PC
中科院分区：
文献类型：
--
作者：
Schrier VJMM;Vrieze A;Amadio PC
腕管包括指屈肌腱和正中神经，它们嵌入一个独特的纤维血管相互连接的滑膜下结缔组织(SSCT)网络中。腕管综合征(CTS)患者存在SSCT的纤维肥大和随后的机械反应适应，但对SSCT的发展知之甚少。这项观察性研究使用组织学和超微结构描述了从晚期胎儿到成年的四个时间点的动物模型中SSCT的形态发展。产后3天至6周之间，从致密的固体SSCT基质过渡到与胶原纤维相连的复杂的多层结构。这些初步数据显示了一种发育模式，与SSCT对负荷和运动的适应性反应相匹配。了解解剖学的发展有助于认识CTS的病理生理学，并支持对新治疗方法的研究。在动物模型中，腕管内的结缔组织在早期发育时显示出特化的结构重组。这种多层结构可能是对肌腱负荷的反应，了解其机制作用有助于理解腕管综合征的病理生理学。
The carpal tunnel contains the digital flexor tendons and the median nerve, which are embedded in a unique network of fibrovascular interconnected subsynovial connective tissue (SSCT). Fibrous hypertrophy of the SSCT and subsequent adaptations in mechanical response are found in patients with carpal tunnel syndrome (CTS), but not much is known about the development of the SSCT. This observational study describes the morphological development of SSCT using histology and ultramicroscopy in an animal model at four time points between late‐term fetuses through adulthood. A transition is seen between 3 days and 6 weeks post‐partum from a dense solid SSCT matrix to a complex multilayered structure connected with collagenous fibrils. These preliminary data show a developmental pattern that matches an adaptive response of the SSCT to loading and motion. Understanding the anatomical development aids in recognizing the pathophysiology of CTS and supports research on new therapeutic approaches. Connective tissue in the carpal tunnel shows specialized structure reorganization in early development in an animal model. The multilayered architecture could be a response to tendon loading and understanding its mechanistic role could aid in understanding carpal tunnel syndrome pathophysiology.
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影响因子：
2.8
作者：
Filius, Anika;Scheltens, Marjan;Selles, Ruud W.
通讯作者：
Selles, Ruud W.
影响因子：
2.8
作者：
Morizaki, Yutaka;Vanhees, Matthias;Amadio, Peter C.
通讯作者：
Amadio, Peter C.
DOI：
10.1016/j.jelekin.2017.10.007
发表时间：
2018-03
期刊：
Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
影响因子：
--
作者：
Festen-Schrier VJMM;Amadio PC
通讯作者：
Amadio PC
DOI：
10.1007/s11552-006-9009-z
发表时间：
2006-12-01
期刊：
Hand (New York, N.Y.)
影响因子：
--
作者：
Ettema, Anke M;Zhao, Chunfeng;Amadio, Peter C
通讯作者：
Amadio, Peter C
影响因子：
4.1
作者：
GILLARD, GC;MERRILEES, MJ;FLINT, MH
通讯作者：
FLINT, MH