Altered sensitization patterns to sweet food stimuli in patients recovered from anorexia and bulimia nervosa.
Altered sensitization patterns to sweet food stimuli in patients recovered from anorexia and bulimia nervosa.
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DOI：
10.1016/j.pscychresns.2015.10.010
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发表时间：
2015-12-30
影响因子：
11.3
通讯作者：
Kaye WH
中科院分区：
文献类型：
--
作者：
Wagner A;Simmons AN;Oberndorfer TA;Frank GK;McCurdy-McKinnon D;Fudge JL;Yang TT;Paulus MP;Kaye WH
最近的研究表明，高阶食欲神经回路可能有助于神经性厌食症（AN）的限制进食和神经性贪食症（BN）的暴食。本研究的目的是确定是否敏化作用可能是病理性进食行为时，味觉刺激反复管理。为了避免营养状态改变的混杂效应，对AN（RAN，n=14）和BN（RBN，n=15）受试者进行了研究。功能性磁共振成像（fMRI）测量了大脑对蔗糖（热量）和三氯蔗糖（无热量）重复味觉的高阶反应。为了测试致敏性，比较了第一次和第二次给药的神经元反应。RAN患者表现出对蔗糖的敏感性降低，而RBN患者表现出相反的模式，对蔗糖的敏感性增加。然而，后者并不像健康对照女性（n=13）那样明显。虽然两个进食障碍亚组显示对三氯蔗糖的敏感性增加，但健康对照组显示敏感性降低。这些发现可以反映在神经元水平上的高热量摄入的RBN在狂欢和低能量摄入的RAN。RAN似乎区分高能量和低能量甜刺激，而RBN没有。
Recent studies show that higher-order appetitive neural circuitry may contribute to restricted eating in anorexia nervosa (AN) and overeating in bulimia nervosa (BN). The purpose of this study was to determine whether sensitization effects might underlie pathologic eating behavior when a taste stimulus is administered repeatedly. Recovered AN (RAN, n=14) and BN (RBN, n=15) subjects were studied in order to avoid the confounding effects of altered nutritional state. Functional magnetic resonance imaging (fMRI) measured higher-order brain response to repeated tastes of sucrose (caloric) and sucralose (non-caloric). To test sensitization, the neuronal response to the first and second administration was compared. RAN patients demonstrated a decreased sensitization to sucrose in contrast to RBN patients who displayed the opposite pattern, increased sensitization to sucrose. However, the latter was not as pronounced as in healthy control women (n=13). While both eating disorder subgroups showed increased sensitization to sucralose, the healthy controls revealed decreased sensitization. These findings could reflect on a neuronal level the high caloric intake of RBN during binges and the low energy intake for RAN. RAN seem to distinguish between high energy and low energy sweet stimuli while RBN do not.
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DOI：
10.1152/ajpgi.00461.2006
发表时间：
2007-07-01
影响因子：
4.5
作者：
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影响因子：
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影响因子：
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作者：
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作者：
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