Chronic exposure to a predator or its scent does not inhibit male-male competition in male mice lacking brain serotonin.
Chronic exposure to a predator or its scent does not inhibit male-male competition in male mice lacking brain serotonin.
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DOI：
10.3389/fnbeh.2014.00116
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发表时间：
2014
影响因子：
3
通讯作者：
Zhang JX
中科院分区：
文献类型：
--
作者：
Huo Y;Fang Q;Shi YL;Zhang YH;Zhang JX
虽然众所周知，大脑中5-HT系统的信号缺陷和压力刺激会导致心理障碍，但它们对男性-男性攻击性和性吸引力的综合影响仍然未知。我们的研究旨在使用色氨酸羟化酶2（Tph 2）敲除雄性小鼠与大鼠或大鼠气味为基础的慢性应激模型来检查这种影响。将Tph 2 +/+和Tph 2 −/−雄性小鼠单独放入大鼠饲养笼（大鼠）、含脏大鼠垫料的笼（大鼠气味）或含新鲜垫料的笼（对照）中，每隔一天放置5 h，连续56天。在Tph 2 +/+雄性小鼠中，大鼠暴露降低了雄性对雄性的攻击和尿气味的性吸引力，与大鼠气味暴露或对照组相比;与对照组相比，大鼠气味暴露降低了尿气味的攻击性而不是性吸引力。然而，这种剂量依赖性和持久的行为抑制作用在Tph 2 −/−雄性小鼠中消失。RT-PCR检测进一步显示，在大鼠或大鼠气味暴露的Tph 2 +/+雄性小鼠中，前额叶皮质中的AR、ERα和GluR 4以及海马中的TrkB-Tc和5-HTR 1A等可能的调控基因在mRNA水平上下调，但在Tph 2 −/−小鼠中部分下调。因此，我们认为，剂量依赖性和持久的抑制作用的长期暴露的捕食者对雄性-雄性侵略，性吸引力的尿气味，和中央调控基因的mRNA表达可能是通过5-HT系统介导的雄性小鼠的大脑。
Although it is well-known that defective signaling of the 5-HT system in the brain and stressful stimuli can cause psychological disorders, their combined effects on male–male aggression and sexual attractiveness remain unknown. Our research aimed at examining such effects using tryptophan hydroxylase 2 (Tph2) knockout male mice vs. a rat- or rat scent-based chronic stress model. Tph2+/+ and Tph2−/− male mice were placed individually into the rat home cage (rat), a cage containing soiled rat bedding (rat scent) or a cage containing fresh bedding (control) for 5 h every other day for 56 consecutive days. In Tph2+/+ male mice, rat-exposure decreased male–male aggression and sexual attractiveness of urine odor relative to either rat scent-exposure or control; and rat scent-exposure decreased aggression rather than sexual attractiveness of urine odor compared with control. However, such dose-dependent and long-lasting behavioral inhibitory effects vanished in Tph2−/− male mice. RT-PCR assay further revealed that putative regulatory genes, such as AR, ERα and GluR4 in the prefrontal cortex, and TrkB-Tc and 5-HTR1A in the hippocampus, were down-regulated at the mRNA level in either rat- or rat scent-exposed Tph2+/+ male mice, but partially in the Tph2−/− ones. Hence, we suggest that the dose-dependent and long-lasting inhibitory effects of chronic predator exposure on male–male aggression, sexual attractiveness of urine odor, and mRNA expression of central regulatory genes might be mediated through the 5-HT system in the brain of male mice.
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影响因子：
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