Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement.
Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement.
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DOI：
10.1016/0896-8411(91)90050-m
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发表时间：
1991-12
影响因子：
12.8
通讯作者：
Klareskog L
中科院分区：
文献类型：
--
作者：
Kleinau S;Erlandsson H;Holmdahl R;Klareskog L
皮内注射不添加其他添加剂的弗氏不完全佐剂油 (FIA) 可在深色刺豚鼠 (DA) 大鼠中诱发糜烂性多关节炎，但在 Lewis 大鼠中则不然。组织学检查显示关节炎症，首先出现多形核细胞和滑膜增生，随后出现多核巨细胞。 FIA 的两种成分、矿物油和 Arlacel® A 以及降植烷油都会导致关节炎，而植物油则不会。恢复后再次给予佐剂油未能诱导关节炎，因此使得特异性免疫在大鼠这种新型关节炎中发挥作用成为可能。
An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.
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影响因子：
3.7
作者：
BEDWELL, AE;ELSON, CJ;HINTON, CE
通讯作者：
HINTON, CE
影响因子：
--
作者：
WARD, JR;JONES, RS
通讯作者：
JONES, RS
影响因子：
5.4
作者：
ROOK, G;THOMPSON, S;RADEMACHER, T
通讯作者：
RADEMACHER, T
影响因子：
56.9
作者：
VLADUTIU, AO;ROSE, NR
通讯作者：
ROSE, NR
影响因子：
56.9
作者：
LIDER, O;RESHEF, T;COHEN, IR
通讯作者：
COHEN, IR