SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes.
SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes.
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Surfin是一种在恶性疟原虫植物和感染的红细胞上表达的多态性抗原。
DOI：
10.1084/jem.20041392
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发表时间：
2005-06-06
影响因子：
15.3
通讯作者：
Wahlgren, M
中科院分区：
文献类型：
--
作者：
Winter, G;Kawai, S;Haeggström, M;Kaneko, O;von Euler, A;Kawazu, SI;Palm, D;Fernandez, V;Wahlgren, M
疟原虫的两个发育阶段，即感染红细胞（IE）和裂殖子的表面将抗原决定簇暴露于宿主免疫系统。我们报告表面相关的散布基因（冲浪基因），它编码一种新的多态性蛋白质家族，SURFINS，目前在IE和裂殖子。一个SURFIN在3D7寄生虫，SURFIN 4.2中表达，通过质谱分析用胰蛋白酶从活IE表面裂解的肽来鉴定。SURFIN由10个surf基因家族编码，包括3个预测的假基因，位于5条染色体的亚端粒内或附近。SURFIN与几种疟原虫的输出表面暴露蛋白（PvSTP 1、PkSICAvar、PvVIR、Pf332和PfEMP 1）显示出结构和序列相似性。除3D7（FCR3S1.2）外的寄生虫的SURFIN 4.2在胞外结构域中显示多态性，表明基因型之间的序列变异性。SURFIN 4.2不仅与PfEMP 1和RIFIN共运输到IE表面，而且在寄主液泡中积累。在释放的裂殖子中，SURFIN 4.2存在于寄生虫顶端的无定形帽中，在那里它可能参与红细胞的侵入。通过暴露IE和裂殖子上共享的多态性抗原，寄生虫可以在血流中生长期间协调这些附着表面的抗原组成。
The surfaces of the infected erythrocyte (IE) and the merozoite, two developmental stages of malaria parasites, expose antigenic determinants to the host immune system. We report on surface-associated interspersed genes (surf genes), which encode a novel polymorphic protein family, SURFINs, present on both IEs and merozoites. A SURFIN expressed in 3D7 parasites, SURFIN4.2, was identified by mass spectrometric analysis of peptides cleaved off the surface of live IEs with trypsin. SURFINs are encoded by a family of 10 surf genes, including three predicted pseudogenes, located within or close to the subtelomeres of five of the chromosomes. SURFINs show structural and sequence similarities with exported surface-exposed proteins (PvSTP1, PkSICAvar, PvVIR, Pf332, and PfEMP1) of several Plasmodium species. SURFIN4.2 of a parasite other than 3D7 (FCR3S1.2) showed polymorphisms in the extracellular domain, suggesting sequence variability between genotypes. SURFIN4.2 not only was found cotransported with PfEMP1 and RIFIN to the IE surface, but also accumulated in the parasitophorous vacuole. In released merozoites, SURFIN4.2 was present in an amorphous cap at the parasite apex, where it may be involved in the invasion of erythrocytes. By exposing shared polymorphic antigens on IEs and merozoites, the parasite may coordinate the antigenic composition of these attachment surfaces during growth in the bloodstream.
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影响因子：
20.3
作者：
Douki, JBL;Sterkers, Y;Gysin, J
通讯作者：
Gysin, J
在恶性疟原虫感染的红细胞表面表达的较小的克隆变异抗原由RIF基因家族编码，并且是人类免疫反应的靶标。
影响因子：
15.3
作者：
Fernandez, V;Hommel, M;Chen, Q;Hagblom, P;Wahlgren, M
通讯作者：
Wahlgren, M
影响因子：
4
作者：
Bannister, LH;Hopkins, JM;Mitchell, GH
通讯作者：
Mitchell, GH
影响因子：
3.1
作者：
Healer, J;Crawford, S;Cowman, AF
通讯作者：
Cowman, AF
DOI：
10.1073/pnas.96.16.9333
发表时间：
1999-08-03
影响因子：
11.1
作者：
Kyes, SA;Rowe, JA;Newbold, CI
通讯作者：
Newbold, CI