Estimated incidence of pertussis in people aged <50 years in the United States.
Estimated incidence of pertussis in people aged <50 years in the United States.
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DOI：
10.1080/21645515.2016.1186313
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发表时间：
2016-10-02
影响因子：
4.8
通讯作者：
Buck PO
中科院分区：
文献类型：
--
作者：
Chen CC;Balderston McGuiness C;Krishnarajah G;Blanchette CM;Wang Y;Sun K;Buck PO
美国在20世纪40年代引入百日咳疫苗接种，大大减轻了其负担。然而，百日咳的发病率难以量化，因为许多病例未经实验室确认或报告，特别是在成人中。这项研究估计了美国50岁以下商业保险人群的百日咳发病率。数据提取自IMS的Pharaoh Plus索赔数据库（使用国际疾病分类（ICD-9）代码诊断为百日咳或咳嗽疾病的患者）、商业门诊实验室数据库（用于百日咳实验室检查的患者）和疾病控制中心流感监测数据库。美国国家百日咳发病率预测使用3种方法：（1）诊断百日咳，定义为百日咳索赔（ICD-9 033.0、033.9、484.3）;（2）基于替代百日咳预测逻辑回归模型;（3）使用归因于实验室确认的百日咳的咳嗽疾病分数（ICD-9 033.0、033.9、484.3、786.2、466.0、466.1、487.1），通过时间序列线性回归模型估计。方法1给出了诊断百日咳的预测年发病率为9/100，000，这在1岁以下的人群中最高。方法2得出的年均预测发病率为21/100，000。方法3给出了总体回归估计的百日咳加权年发病率为649/100，000，根据年份，大约比方法1高58-93倍。这些估计与50岁以下人群中百日咳的大量漏报相一致，并进一步证明大多数病例未被发现，特别是随着年龄的增长，可能有助于制定公共卫生计划以减少百日咳负担。
The introduction of pertussis vaccination in the United States (US) in the 1940s has greatly reduced its burden. However, the incidence of pertussis is difficult to quantify, as many cases are not laboratory-confirmed or reported, particularly in adults. This study estimated pertussis incidence in a commercially insured US population aged <50 years. Data were extracted from IMS' PharMetrics Plus claims database for patients with a diagnosis of pertussis or cough illness using International Classification of Diseases (ICD-9) codes, a commercial outpatient laboratory database for patients with a pertussis laboratory test, and the Centers for Disease Control influenza surveillance database. US national pertussis incidence was projected using 3 methods: (1) diagnosed pertussis, defined as a claim for pertussis (ICD-9 033.0, 033.9, 484.3) during 2008–2013; (2) based on proxy pertussis predictive logistic regression models; (3) using the fraction of cough illness (ICD-9 033.0, 033.9, 484.3, 786.2, 466.0, 466.1, 487.1) attributed to laboratory-confirmed pertussis, estimated by time series linear regression models. Method 1 gave a projected annual incidence of diagnosed pertussis of 9/100,000, which was highest in those aged <1 year. Method 2 gave an average annual projected incidence of 21/100,000. Method 3 gave an overall regression-estimated weighted annual incidence of pertussis of 649/100,000, approximately 58–93 times higher than method 1 depending on the year. These estimations, which are consistent with considerable underreporting of pertussis in people aged <50 years and provide further evidence that the majority of cases go undetected, especially with increasing age, may aid in the development of public health programs to reduce pertussis burden.
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影响因子：
3.6
作者：
Paget, W. John;Balderston, Catherine;Casas, Inmaculada;Donker, Ge;Edelman, Laurel;Fleming, Douglas;Larrauri, Amparo;Meijer, Adam;Puzelli, Simona;Rizzo, Caterina;Simonsen, Lone
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Simonsen, Lone
影响因子：
120.7
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Thompson, WW;Shay, DK;Fukuda, K
通讯作者：
Fukuda, K
影响因子：
3.7
作者：
McGuiness CB;Hill J;Fonseca E;Hess G;Hitchcock W;Krishnarajah G
通讯作者：
Krishnarajah G
影响因子：
4.2
作者：
M端ller-Pebody, B;Edmunds, WJ;Crowcroft, NS
通讯作者：
Crowcroft, NS
影响因子：
120.7
作者：
Misegades, Lara K.;Winter, Kathleen;Martin, Stacey W.
通讯作者：
Martin, Stacey W.