From complete genome sequence to 'complete' understanding?
From complete genome sequence to 'complete' understanding?
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DOI：
10.1016/j.tibtech.2010.05.006
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发表时间：
2010-08
影响因子：
17.3
通讯作者：
Koonin, Eugene V.
中科院分区：
文献类型：
--
作者：
Galperin, Michael Y.;Koonin, Eugene V.
快速积累的基因组序列数据使研究人员甚至在几年前都没有提出的基本生物学问题，这是基因组的主要问题。测序基因组。我们讨论了基因组生物学的两个关键问题：我们是否需要更多的基因组分析。我们认为，基于蛋白质家族分类的基因功能过于特定的基因功能的特定注释也不是更稳健的功能分配。
The rapidly accumulating genome sequence data allow researchers to address fundamental biological questions that were not even asked just a few years ago. A major problem in genomics is the widening gap between the rapid progress in genome sequencing and the comparatively slow progress in the functional characterization of sequenced genomes. Here we discuss two key questions of genome biology: whether we need more genomes, and how deep is our understanding of biology based on genomic analysis. We argue that overly specific annotations of gene functions are often less useful than the more generic, but also more robust, functional assignments based on protein family classification. We also discuss problems in understanding the functions of the remaining “conserved hypothetical” genes.
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影响因子：
14.9
作者：
Jensen LJ;Kuhn M;Stark M;Chaffron S;Creevey C;Muller J;Doerks T;Julien P;Roth A;Simonovic M;Bork P;von Mering C
通讯作者：
von Mering C
影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
影响因子：
4.2
作者：
Galperin MY
通讯作者：
Galperin MY
影响因子：
3.2
作者：
Christopherson, Melissa R.;Schmitz, G. E.;Downs, Diana M.
通讯作者：
Downs, Diana M.
影响因子：
3.2
作者：
Handford, Jennifer I.;Ize, Berengere;Palmer, Tracy
通讯作者：
Palmer, Tracy