Genetic diversity of bats coronaviruses in the Atlantic Forest hotspot biome, Brazil.

Genetic diversity of bats coronaviruses in the Atlantic Forest hotspot biome, Brazil.
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DOI:
10.1016/j.meegid.2016.07.034
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发表时间:
2016-10
期刊:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子:
--
通讯作者:
Durigon EL
Durigon EL
中科院分区:
其他
文献类型:
--
作者:
Góes LGB;Campos ACA;Carvalho C;Ambar G;Queiroz LH;Cruz-Neto AP;Munir M;Durigon EL

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蝙蝠是臭名昭著的遗传多样性和高调病原体的水库,并在人类和动物中病毒的出现和重新出现中发挥着至关重要的作用。在这份报告中,我们在巴西的大西洋森林生物群落中鉴定并表征了以前未知的和多样化的蝙蝠冠状病毒遗传簇。这些结果突出了蝙蝠的病毒丰富性及其在公共卫生中可能发挥的作用。我们描述了AFB蝙蝠中的CoV谱系,13 α-CoV和2 β-CoV的循环。在8个蝙蝠物种的15个蝙蝠样本中检测到冠状病毒(50%阳性)。在Sturnira蝙蝠中检测到一簇α-CoV,其与α-CoV谱系-1分组。我们鉴定了两种不同的β-CoV,其在含有谱系C的MERS-CoV内聚集。结果突出了蝙蝠的病毒丰富性及其在公共卫生中的可能作用。
Bats are notorious reservoirs of genetically-diverse and high-profile pathogens, and are playing crucial roles in the emergence and re-emergence of viruses, both in human and in animals. In this report, we identified and characterized previously unknown and diverse genetic clusters of bat coronaviruses in the Atlantic Forest Biome, Brazil. These results highlight the virus richness of bats and their possible roles in the public health. We describe the circulation of CoV lineages, 13 α-CoV and two β-CoV in AFB bats. Coronaviruses were detected in 15 bat samples from eight bat species (50% positivity). A cluster of α-CoVs were detected in Sturnira bat that grouped with α-CoVs lineage-1. We identified two distinct β-CoV that clustered within MERS-CoV containing lineage C. Results highlight the virus richness of bats and their possible roles in the public health.
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