Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease
Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease
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多巴胺替代改变帕金森病复杂双手手指运动过程中皮质前额叶、前运动和运动区域的有效连接
DOI：
10.1016/j.neuroimage.2018.04.030
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发表时间：
2018
期刊：
影响因子：
5.7
通讯作者：
Esther Annegret
中科院分区：
文献类型：
--
作者：
Nettersheim;Felix Sebastian;Loehrer;Philipp Alexander;Fabienne;Dembek;Till Anselm;Pelzer;Esther Annegret
帕金森病(PD)患者的双手协调功能受损，影响患者的生活质量。除了基底节网络的功能障碍外，皮质振荡耦合的改变，特别是前额叶和(前)运动区之间的变化，被认为是这种损害的基础。在这里，我们研究了16名不服药和不服药的帕金森病患者和年龄匹配的健康对照组，记录了在空间耦合和非耦合双手指运动过程中的高分辨率脑电(EEG)。诱发反应的动态因果模型(DCM)被用来推断由双侧前额叶皮质(PFC)、外侧运动前皮质(LPM)、辅助运动区(SMA)和初级运动皮质(M1)组成的网络中任务诱导的有效连接。在进行空间耦合运动时，与未用药的PD患者相比，对照组兴奋性左半球PFC到LPM的耦合显著增强。左旋多巴诱导的这种联系的增强与运动准确性的增加相关。在空间分离运动中，停药的帕金森病患者表现出从左侧PFC到SMA的抑制连接。摄入左旋多巴可减弱这些抑制作用，并恢复兴奋性PFC至LPM的偶联。结论：帕金森病患者前额叶至运动前连接的偏侧化可通过左旋多巴替代而增强，且在一定程度上具有代偿性。
Bimanual coordination is impaired in Parkinson's disease (PD), affecting patients' quality of life. Besides dysfunction of the basal ganglia network, alterations of cortical oscillatory coupling, particularly between prefrontal and (pre-)motoric areas, are thought to underlie this impairment. Here, we studied 16 PD patients OFF and ON medication and age-matched healthy controls recording high-resolution electroencephalography (EEG) during performance of spatially coupled and uncoupled bimanual finger movements. Dynamic causal modeling (DCM) for induced responses was used to infer task-induced effective connectivity within a network comprising bilateral prefrontal cortex (PFC), lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1). Performing spatially coupled movements, excitatory left-hemispheric PFC to lPM coupling was significantly stronger in controls compared to unmedicated PD patients. Levodopa-induced enhancement of this connection correlated with increased movement accuracy. During performance of spatially uncoupled movements, PD patients OFF medication exhibited inhibitory connectivity from left PFC to SMA. Levodopa intake diminished these inhibitory influences and restored excitatory PFC to lPM coupling. This restoration, however, did not improve motor function.Concluding, our results indicate that lateralization of prefrontal to premotor connectivity in PD can be augmented by levodopa substitution and is of compensatory nature up to a certain extent of complexity.
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DOI：
10.1093/cercor/bht140
发表时间：
2014-11
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Herz DM;Florin E;Christensen MS;Reck C;Barbe MT;Tscheuschler MK;Tittgemeyer M;Siebner HR;Timmermann L
通讯作者：
Timmermann L
左旋多巴可提高帕金森病患者交替运动的速度
影响因子：
3.3
作者：
T. Müller;S. Peters;A. Harati
通讯作者：
A. Harati
影响因子：
2.5
作者：
Heinrichs-Graham, Elizabeth;Kurz, Max J.;Wilson, Tony W.
通讯作者：
Wilson, Tony W.
DOI：
10.1093/brain/awq381
发表时间：
2011-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
L. Timmermann;G. Fink
通讯作者：
L. Timmermann;G. Fink
影响因子：
5.7
作者：
Herz, Damian M.;Siebner, Hartwig R.;Timmermann, Lars
通讯作者：
Timmermann, Lars