Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model.
Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model.
复制标题
补中益气丸缓解4T1小鼠乳腺癌模型化疗相关疲劳
DOI：
10.1186/1472-6882-14-497
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发表时间：
2014-12-15
影响因子：
--
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Ouyang M;Liu Y;Tan W;Xiao Y;Yu K;Sun X;Huang Y;Cheng J;Luo R;Zhao X
研究背景由于对其病理生理机制的认识有限和缺乏有效的治疗手段，太平洋运动性疲劳仍然没有得到充分的认识和治疗。本研究旨在探讨补中益气丸对紫杉醇治疗小鼠4 T1乳腺癌的抗疲劳作用及其机制。阴性对照组（NC）、肿瘤对照组（TC）、紫杉醇组（PTX）、补中益气丸组（BZYQ）和补中益气丸+紫杉醇组（BZYQ + PTX）。给小鼠施用21天。在此期间，测量肿瘤体积、体重和负重游泳时间。末次给药后处死小鼠，称重肿瘤重量，测定免疫细胞因子和氧化应激指标。结果BZYQ + PTX组和PTX组分别在第9天和第18天开始与TC组相比，肿瘤体积明显缩小（P < 0.05-0.01），肿瘤重量明显减轻（P <0.05 - 0.01）。BZYQ + PTX组、BZYQ组和PTX组小鼠的中位生存时间和平均生存时间均较TC组明显延长（P < 0.05-0.01）。BZYQ + PTX组小鼠游泳时间逐渐增加，第14、21天明显长于PTX组（P < 0.01）。补阳还五汤+ PTX组TNF-α水平低于PTX组（P < 0.01）。补阳还五汤+ PTX组SOD活性低于NC组（P <0.01），但明显高于PTX组（P < 0.01）。BZYQ + PTX组MDA水平高于NC组（P < 0.01），但显著低于PTX组（P <0.01）。结论BZYQ可通过降低TNF-α水平，调节MDA水平和SOD活性，减轻紫杉醇化疗所致的4 T1乳腺癌小鼠疲劳。
BackgroundPaclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding of its pathophysiology and lack of effective treatments. This study is aim to evaluate the anti-fatigue effects and mechanism of Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel.MethodsBreast cancer mice established with murine 4 T1 cells were randomly and repectively divided into five groups: negative control group (NC), tumor control group (TC), paclitaxel group (PTX), Bu-Zhong-Yi-Qi pill group (BZYQ) and Bu-Zhong-Yi-Qi pill plus paclitaxel group (BZYQ + PTX). The mice were administered for 21 days. During this period, the tumor volume, body weight and the weight-loaded swimming time were measured. After the last administration, all mice were sacrificed, weighted the tumor, measured immune cell cytokines and oxidative stress indicator. The remaining 10 mice in each group were observed for survival analysis.ResultsTreatments with BZYQ + PTX and PTX significantly reduced the rates of tumor volume in comparison with TC starting on the 9th day and the 18th day respectively (P < 0.05-0.01), and presented decreased tumor weight compared to TC (P < 0.05-0.01). Compared with mice in TC group, the median survival time and the average survival time in BZYQ + PTX group, BZYQ group and PTX group were significantly prolonged (P < 0.05-0.01). The swimming time of the BZYQ + PTX group gradually increased, which is longer than the PTX group on Day 14 and Day 21 (P < 0.01). The level of TNF-α was lower in BZYQ + PTX group than PTX group (P < 0.01). The level of SOD activity in BZYQ + PTX group was lower than the NC group (P <0.01), but much higher than the PTX group (P < 0.01). The level of MDA of BZYQ + PTX group was higher than the NC group (P < 0.01), but significant lower than the PTX group (P < 0.01).ConclusionsBZYQ has the potential of alleviating paclitaxel chemotherapy-related fatigue in 4 T1 breast cancer mice by reducing the serum levels of TNF-α and modulating the level of MDA and the SOD activity.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1016/0952-3278(91)90144-t
发表时间：
1991-09-01
影响因子：
3
作者：
CHANG, WC;HSU, FL
通讯作者：
HSU, FL
影响因子：
3.3
作者：
Hardin, Brian J.;Campbell, Kenneth S.;Reid, Michael B.
通讯作者：
Reid, Michael B.
影响因子：
3.3
作者：
Chen, Rui;Moriya, Junji;Yoshizaki, Fumihiko
通讯作者：
Yoshizaki, Fumihiko
影响因子：
2.9
作者：
Harden, Lois M.;du Plessis, Irne;Laburn, Helen P.
通讯作者：
Laburn, Helen P.