3D Printed Zn-doped Mesoporous Silica-incorporated Poly-L-lactic Acid Scaffolds for Bone Repair.
3D Printed Zn-doped Mesoporous Silica-incorporated Poly-L-lactic Acid Scaffolds for Bone Repair.
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DOI：
10.18063/ijb.v7i2.346
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发表时间：
2021
影响因子：
8.4
通讯作者：
Shuai C
中科院分区：
文献类型：
--
作者：
Qian G;Zhang L;Wang G;Zhao Z;Peng S;Shuai C
聚左旋乳酸（PLLA）缺乏成骨活性，限制了其在骨修复中的应用。锌（Zn）由于其优异的成骨活性而被广泛应用于增强聚合物的生物性能。在本研究中，采用一锅水热法合成了锌掺杂介孔二氧化硅（Zn-MS）颗粒。然后，将颗粒诱导成通过选择性激光烧结技术制备的PLLA支架，旨在提高其成骨活性。结果表明，合成的颗粒具有玫瑰花状的形貌和均匀的介孔结构，复合支架在低浓度范围内表现出锌离子的持续释放，这归因于PLLA基质的屏蔽效应和Si-O-Zn的强键合相互作用。该支架可以通过上调成骨相关基因的表达来明显促进小鼠骨髓间充质干细胞的成骨分化。此外，Zn-MS颗粒由于其玫瑰花状形态和介孔结构，可以显着提高PLLA支架的抗压强度，可以与PLLA基质形成微机械联锁。 Zn-MS颗粒由于其有利的形态和物理化学性质而具有改善各种聚合物支架性能的巨大潜力。
Poly-L-lactic acid (PLLA) lacks osteogenic activity, which limits its application in bone repair. Zinc (Zn) is widely applied to strengthen the biological properties of polymers due to its excellent osteogenic activity. In the present study, Zn-doped mesoporous silica (Zn-MS) particles were synthesized by one-pot hydrothermal method. Then, the particles were induced into PLLA scaffolds prepared by selective laser sintering technique, aiming to improve their osteogenic activity. Our results showed that the synthesized particles possessed rosette-like morphology and uniform mesoporous structure, and the composite scaffold displayed the sustained release of Zn ion in a low concentration range, which was attributed to the shield effect of the PLLA matrix and the strong bonding interaction of Si-O-Zn. The scaffold could evidently promote osteogenesis differentiation of mouse bone marrow mesenchymal stem cells by upregulating their osteogenesis-related gene expression. Besides, Zn-MS particles could significantly increase the compressive strength of the PLLA scaffold because of their rosette-like morphology and mesoporous structure, which can form micromechanical interlocking with the PLLA matrix. The Zn-MS particles possess great potential to improve various polymer scaffold properties due to their advantageous morphology and physicochemical properties.
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