Competitive interactions between cells: death, growth, and geography.

Competitive interactions between cells: death, growth, and geography.
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DOI:
10.1126/science.1163862
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发表时间:
2009-06-26
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Johnston LA
Johnston LA
中科院分区:
其他
文献类型:
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作者:
Johnston LA

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细胞间的竞争性相互作用是生物学中许多稳态过程的基础。一些被描述得最好的细胞间竞争案例发生在果蝇身上:细胞竞争,即生长上皮内的体细胞相互竞争,为成体细胞做出贡献;干细胞竞争,即生殖细胞或体细胞干细胞争夺生态位。这两种类型的竞争都是保守的生理过程,告诉我们细胞邻里如何影响细胞行为,并对干细胞生物学、再生和移植以及癌症具有重要意义。
Competitive interactions between cells are the basis of many homeostatic processes in biology. Some of the best-described cases of competition between cells occur in Drosophila: cell competition, whereby somatic cells within a growing epithelium compete with one another for contribution to the adult, and stem cell competition, in which germline or somatic stem cells vie for residency in the niche. Both types of competition are conserved physiological processes, with much to tell us about how cellular neighborhoods influence cell behavior, and have importance to stem cell biology, regeneration and transplantation, and cancer.
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